Arizona Wildcats vs Iowa State Cyclones Prediction, 9/27/2025 College Football Picks, Best Bets & Odds

Game: Arizona Wildcats vs Iowa State Cyclones

Date: Saturday, September 27, 2025

Location: Jack Trice Stadium in Ames, IA

TV: ESPN

Odds/Point Spread: Cyclones (-6.5)

Total/Over-Under: 50

Jack Trice Stadium is where the Iowa State Cyclones (4-0) will take on the Arizona Wildcats (3-0) on Saturday, September 27, 2025. Iowa State is 6.5-point favorites. The total is set at 50.

The Arizona Wildcats come into this matchup with a record of 3-0 this year. In their last contest, the Wildcats played the Kansas State Wildcats and earned the victory with a final of 23-17. On the ground, the Wildcats conceded 105 yds on 24 attempts, which is an average of 4.4 yds per rush allowed. Arizona relinquished 13 pass completions on 29 tries for 88 yards, and a completion percentage of 44.8%. At the end of the game, they had 79 plays which gave them 412 yards. The Arizona Wildcats ended up rushing 45 different times and tallied 234 yards, which is an average of 5.2 yds per carry.

The Wildcats have earned 1,312 yards in total over the course of this year. When it comes to getting the ball in the endzone, Arizona has compiled 6 touchdowns via the pass and 6 touchdowns via the ground. They have surrendered the football 2 different times. Arizona has accrued 68 first downs as a unit, and they have been hurt by 25 infractions for 190 yards. As a unit they're averaging 189.0 yards via the ground game ranking this team at 49th in Division 1. Regarding putting the ball in the endzone, the Arizona Wildcats have an average of 37.0 points per outing.

When it comes to passing yards, the Wildcats are giving up 379 yds which puts them in 9th in D-1. They have yielded 126.3 yards per outing via the pass as well as conceding a completion percentage of 48.9%. Over the course of this year, they have surrendered 222.3 yards/game which puts them 7th in Division 1. They have yielded 0 touchdowns through the air as well as 2 touchdowns on the ground. The opposition is running for 3.4 yards per attempt on the ground and 96.0 rushing yards per game for the year. Over the course of this year, they have conceded 288 yards via the ground game in 3 games. The Wildcats rank 7th in D-1 when it comes to the opposition scoring, conceding 8.7 points per game.

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The Cyclones come into this game with a record of 4-0 for this year. When they last stepped on the field, the Cyclones walked away with a victory by a final of 24-16 when they faced the Arkansas State Red Wolves. The Cyclones finished the game with 452 yds on 59 plays (7.7 yds per play). Iowa State ended up running for 5.5 yds per carry, finishing the contest with 187 yards on 34 carries. Iowa State surrendered 40 run attempts for 160 yards (4.0 yards per carry). The Cyclones secondary conceded a completion rate of 57.6%, relinquishing 222 yards on 19 out of 33 through the air.

The Iowa State Cyclones have an average of 383.0 yards per game, which is good for 79th in the nation. The Iowa State offense has 108 yds of penalties on 12 violations, ranking them 128th in the nation in terms of helping out the opposition. They maintain an average of 161.0 yards per game on the ground and have run for 644 yards overall. They have tossed 1 picks while losing 3 fumbles and they have been able to tally 81 1st downs. Regarding this team's ability to score points, the Cyclones currently rank 74th in the country scoring 29.8 points per outing. During the season thus far, the Cyclones have earned 888 yards via the pass in addition to an average of 222.0 throwing yards per contest, which ranks 74th in the nation.

The Cyclones are relinquishing 14.3 PPG, which puts them 22nd in D-1. Iowa State has allowed a total of 484 yards rushing (121.0 yards per game) in addition to 3 touchdowns via the rush for the season. They have yielded 3 touchdowns from the passing game in addition to 176.0 yards per game, which puts them in 35th in the nation. The Cyclones defense has taken the field for 244 plays, which is 65th in college football. They have earned 2 fumbles and 4 interceptions so far this season. Overall, they have surrendered 57 points.

Who will win tonight's Wildcats/Cyclones college football game against the spread?

Josh's Pick: Take the Cyclones -6.5

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