BYU Cougars vs Colorado Buffaloes Prediction, 9/27/2025 College Football Picks, Best Bets & Odds

Game: BYU Cougars vs Colorado Buffaloes

Date: Saturday, September 27, 2025

Location: Folsom Field in Boulder, CO

TV: ESPN

Odds/Point Spread: Buffaloes (+6.5)

Total/Over-Under: 47

The Colorado Buffaloes (2-2) will play the BYU Cougars (3-0) at Folsom Field on Saturday, September 27, 2025. BYU opens this game as 6.5-point favorites. The over/under is set at 47.

The BYU Cougars head into this game 3-0 for this year. The last time they took the field, the Cougars played the East Carolina Pirates and walked away with a win by a score of 34-13. In the game, they ran 60 plays which gave them 418 yards. The BYU Cougars ran the ball 34 different times and accrued 172 yards, which came out to an average of 5.1 yards per tote. On the ground, the Cougars gave up 119 yards on 35 tries, which is an average of 3.4 yds per run surrendered. BYU allowed 25 pass completions on 42 attempts for a total of 285 yds, and a completion rate of 59.5%.

In terms of scoring points, the BYU Cougars are sitting at 43.3 PPG. As a team they're holding an average of 265.7 yards via the ground game which is 7th in college football. The Cougars have earned 1,356 total yards over the course of this season. With reference to scoring touchdowns, BYU has amassed 4 passing touchdowns and 9 touchdowns on the ground. BYU has accumulated 66 1st downs offensively, and they have been called for 19 penalties for 191 yds. They have turned the football over 1 time.

Concerning yards through the air, the Cougars are allowing 483 yds which ranks them 15th in college football. They have yielded 161.0 yards per outing through the air as well as conceding a completion percentage of 55.3%. Over the course of this year, they have given up 205.3 yards per outing ranking them 2nd in the nation. They have allowed 0 touchdowns by air and 1 touchdown on the ground. The opposition is running for an average of 1.6 yards per run and 44.3 yards on the ground per contest on the year. In total, they have conceded 133 rushing yards through 3 outings. The Cougars rank 2nd in D-1 regarding team defense, conceding 5.3 PPG.

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The Buffaloes step onto the field holding a record of 2-2 for this season. In their last game, the Buffaloes got the victory with a final of 37-20 when they faced the Wyoming Cowboys. Colorado gave up 41 run attempts for 165 yds (4.0 yards per carry). The Buffaloes secondary gave up a completion rate of 46.2%, surrendering 182 yds on 12 out of 26 passing. The Buffaloes finished the game with 497 yards while running 59 plays (8.4 yds per play). Colorado ran for 6.2 yds per attempt, finishing with a total of 193 yds on 31 carries.

The Colorado Buffaloes average 375.0 yards/game, ranking them 83rd in the nation. The Colorado offense has 183 penalty yards on 20 violations, ranking them 90th in college football in terms of giving up free yards. They hold an average of 141.3 yards per game via the ground game and have rushed for 565 yards in total. They have thrown 2 interceptions while letting opponents recover 1 fumble and they have been able to earn 78 first downs. Regarding this team's ability to score points, the Buffaloes are 83rd in the country by tallying 27.0 PPG. For the season to this point, the Buffaloes have thrown for a total of 935 passing yards in addition to an average of 233.8 passing yards per contest, putting them at 68th in D-1.

The Buffaloes are conceding 22.5 points per game, which has them sitting 66th in D-1. Colorado has yielded a total of 778 yards via the ground game (194.5 yards per outing) and 6 touchdowns rushing this year. They have allowed the opposition 3 touchdowns via the pass and 214.8 yards/game, which puts them in 79th in the country. The Buffaloes defense has participated in 278 plays, which ranks 114th in D-1. They have 3 fumbles recovered and 2 interceptions on the season. Overall, they have given up 90 pts.

Who will win tonight's Cougars/Buffaloes college football game against the spread?

Guy's Pick: Take the Buffaloes +6.5

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