California Golden Bears vs Louisville Cardinals Prediction, 11/8/2025 College Football Picks, Best Bets & Odds

Game: California Golden Bears vs Louisville Cardinals

Date: Saturday, November 8, 2025

Location: L&N Federal Credit Union Stadium in Louisville, KY

TV: ESPN2

Odds/Point Spread: Cardinals (-19.5)

Total/Over-Under: 50.5

L&N Federal Credit Union Stadium is the location where the Louisville Cardinals (7-1) will compete against the California Golden Bears (5-4) on Saturday, November 8, 2025. California opens this contest as 19.5-point underdogs. The total is 50.5.

The California Golden Bears come into this matchup with a record of 5-4 for this year. In their last matchup, the Golden Bears faced the Virginia Cavaliers and went home with a loss by a final score of 31-21. When all was said and done, they ran 57 plays which converted into 263 yards. The California Golden Bears ran the ball a total of 25 different times and totaled 8 yds, which had them averaging 0.3 yds per carry. When it came to the battle of the line of scrimmage, the Golden Bears gave up 194 yards on 44 attempts, which calculates to 4.4 yards per rush allowed. California surrendered 24 completions on 36 tries for 262 yds, and a completion rate of 66.7%.

Concerning scoring points, the California Golden Bears hold an average of 24.6 PPG. As a team they are averaging 78.6 yards on the ground ranking them 135th in college football. The Golden Bears have attained 2,992 total yards over the course of this year. In terms of distribution of touchdowns, California has totaled 13 touchdowns via the pass and 15 touchdowns via the ground. California has accounted for 169 first downs offensively, and they have committed 65 infractions for 500 yds. They have surrendered the ball 12 different times.

The Golden Bears are sitting in 74th in the nation when it comes to team defense, allowing 25.1 PPG. They are allowing teams to run for an average of 4.5 yards per run and 156.6 rushing yards per contest on the campaign. For the year, they have conceded 1,409 rushing yards through 9 games. When it comes to yards through the air, the Golden Bears have given up 1,789 yds which has them ranked 54th in Division 1. They have given up 198.8 yards per contest through the air and conceding a completion percentage of 61.9%. During this campaign, they are conceding 355.3 yards/game putting them 57th in Division 1. They have surrendered 7 touchdowns via the pass as well as 18 touchdowns pounding the rock.

Get all of our Free College Football Picks

The Cardinals head into this game 7-1 for this season. In their last game, the Cardinals got the win with a final of 28-16 when they faced the Virginia Tech Hokies. The Cardinals finished the game with 371 yards while running 62 plays (6.0 yds per play). Louisville ran the ball for 6.9 yards per tote, finishing with a total of 235 yds on 34 attempts. Louisville relinquished 40 attempts on the ground for 164 yds (4.1 yds per carry). The Cardinals passing defense conceded a completion percentage of 45.8%, relinquishing 76 yards on 11 for 24 through the air.

Regarding the points being put on the board, the Cardinals are 37th in D-1 holding an average of 33.8 points per game. The Louisville Cardinals average 407.8 yards per outing, ranking them 60th in Division 1. The Louisville offense has compiled 523 yds of penalties on 55 violations, which is 53rd in the country in terms of giving up free yards. They have tossed 7 interceptions while surrendering 6 fumbles and they have earned 165 1st downs. During the season to this point, the Cardinals have compiled 2,016 passing yards in addition to an average of 252.0 passing yards per outing, ranking them 46th in college football. They have an average of 155.8 run yards per game and have run for 1,246 yards in total.

Louisville has surrendered a total of 901 yards rushing (112.6 yards/game) and 7 touchdowns by way of the ground game this season. They have allowed 9 touchdowns from the passing game and 167.9 yards per outing, which has them sitting 17th in D-1. This year, they have allowed 166 total points. Their defense has totaled 4 fumbles recovered and 12 interceptions this year. The Cardinals defense has been on the field for 504 plays, which is 15th in the country. The Cardinals are relinquishing 20.8 points per game, which has them sitting 34th in D-1.

Who will win tonight's Golden Bears/Cardinals college football game against the spread?

Tony's Pick: Take the Golden Bears +19.5

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get college football picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.