Central Michigan Chippewas vs Pittsburgh Panthers Prediction, 9/6/2025 College Football Picks, Best Bets & Odds

Game: Central Michigan Chippewas vs Pittsburgh Panthers

Date: Saturday, September 6, 2025

Location: Acrisure Stadium in Pittsburgh, PA

TV: ESPN/ESPN+

Odds/Point Spread: Panthers (-22.0)

Total/Over-Under: 52

The Central Michigan Chippewas (1-0) are on their way to Acrisure Stadium on Saturday, September 6, 2025 where they will go up against the Pittsburgh Panthers (1-0). Pittsburgh opens this game as 22.0-point favorites. The total is set at 52.

The Central Michigan Chippewas come into this matchup with a record of 1-0 for this season. In their last game, the Chippewas faced the San Jose State Spartans and earned the victory with a final of 16-14. For the game, they had 64 plays which totaled 351 yds. The Central Michigan Chippewas ran the ball 51 different times and accounted for 236 yards, which is an average of 4.6 yds per carry. Against the rush, the Chippewas conceded 75 yds on 24 attempts, which calculates to 3.1 yds per run allowed. Central Michigan conceded 24 completions on 45 tries for 308 yards, and a completion percentage of 53.3%.

Regarding scoring points, the Central Michigan Chippewas hold an average of 16.0 points per game. Offensively they're averaging 236.0 yards via the ground game which has them sitting 27th in D-1. The Chippewas have tallied 351 total yards for this campaign. When it comes to getting the ball in the endzone, Central Michigan has compiled 1 touchdown on the ground. Central Michigan has 20 1st downs, and they have been called for 7 infractions for 33 yds. They have yet to turn the ball over.

The Chippewas are sitting in 63rd in Division 1 concerning team defense, allowing 14.0 PPG. They are allowing 3.1 yards per rushing attempt and 75.0 yards on the ground per game this season. In total, they have conceded 75 rushing yards through 1 game. When it comes to yards via the pass, the Chippewas are giving up 308 yards which has them ranked 121st in the nation. They have yielded 308.0 yards per contest via the pass and giving up a completion percentage of 53.3%. During this campaign, they have surrendered 383.0 yards per contest which has them ranked 103rd in the country. They have surrendered 2 touchdowns via the pass.

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The Panthers head into this game 1-0 this season. When they last stepped on the gridiron, the Panthers got the victory with a final of 61-9 against the Duquesne Dukes. The Panthers finished with a total of 460 yds while running 65 plays (7.1 yards per play). Pittsburgh rushed the ball for 5.9 yards per attempt, finishing with a total of 158 yards on 27 attempts. Pittsburgh allowed 31 rush attempts for 37 yards (1.2 yds per carry). The Panthers secondary allowed a completion percentage of 63.0%, surrendering 171 yards on 17 out of 27 through the air.

Regarding how much they score, the Panthers rank 7th in the nation by scoring 61.0 points per outing. The Pittsburgh Panthers hold an average of 460.0 yards per game, which has them sitting 36th in the country. The Pittsburgh offense has compiled 35 yards of penalties on 3 infractions, which ranks them 114th in D-1 in terms of giving up free yards. They have been able to record 21 1st downs. For the year so far, the Panthers have earned 302 passing yards, which is ranked 22nd in the country. They have an average of 158.0 yards per game.

The Panthers are conceding 9.0 PPG, ranking them 36th in D-1. Pittsburgh has allowed a total of 37 yards on the ground. They have allowed 1 touchdown via the pass and 171.0 yards/contest, ranking them 65th in the country. The Panthers defense has taken part in 58 plays, which has them ranked 36th in D-1. They have yet to force a turnover.

Who will win tonight's Chippewas/Panthers college football game against the spread?

Tony's Pick: Take the Panthers -22.0

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