Clemson Tigers vs South Carolina Gamecocks Prediction, 11/29/2025 College Football Picks, Best Bets & Odds

Game: Clemson Tigers vs South Carolina Gamecocks

Date: Saturday, November 29, 2025

Location: Williams-Brice Stadium in Columbia, SC

TV: SEC Network

Odds/Point Spread: Gamecocks (-3.0)

Total/Over-Under: 46

Williams-Brice Stadium is the location where the South Carolina Gamecocks (4-7) will meet the Clemson Tigers (6-5) on Saturday, November 29, 2025. Clemson opens as 3.0-point underdogs. The over/under is set at 46.

The Clemson Tigers come into this game with a record of 6-5 this year. In their last game, the Tigers faced the Furman Paladins and walked away with a win by a score of 45-10. The Clemson Tigers ran the ball 31 times and compiled 219 yds, which came out to an average of 7.1 yards per carry. At the end of the game, they tallied 67 plays which totaled 456 yds. Clemson conceded 25 pass completions on 42 attempts for a total of 205 yds, and a completion percentage of 59.5%. Against the run, the Tigers conceded 66 yards on 28 tries, which averages out to 2.4 yards per rush surrendered.

The Tigers currently have 4,448 total yards for the year. In terms of distribution of touchdowns, Clemson has earned 22 touchdowns via the pass and 17 touchdowns via the ground. They have turned the ball over 14 different times. Clemson has recorded 233 first downs as a unit, and they have committed 50 penalties for 497 yards. As a team they average 129.8 yards on the ground which ranks them 98th in college football. In terms of getting in the endzone, the Clemson Tigers are averaging 28.7 PPG.

The Tigers are sitting in 35th in the country in terms of team defense, giving up 21.0 PPG. Opposing teams are running for an average of 3.6 yards per run and 108.5 rushing yards per contest for the campaign. During the season, they have conceded 1,194 rushing yards through 11 games. When talking about passing yards, the Tigers are allowing 2,625 yards which has them ranked 93rd in the nation. They are conceding 238.6 yards per outing via the pass in addition to giving up a completion percentage of 60.8%. For the season, they are granting 347.1 yards/game which puts them 46th in college football. They have yielded 14 touchdowns via the pass in addition to 10 touchdowns running the ball.

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The Gamecocks step onto the field holding a record of 4-7 for this season. When they last played, the Gamecocks walked away with a victory by a final of 51-7 against the Coastal Carolina Chanticleers. South Carolina ran the football for 6.8 yards per attempt, finishing the game with 264 yds on 39 attempts. The Gamecocks finished the game with 579 yards while they ran 69 plays (8.4 yards per play). The Gamecocks pass defense allowed a completion percentage of 75.0%, relinquishing 174 yards on 27 for 36 passing. South Carolina gave up 29 run attempts for 38 yds (1.3 yds per rush).

The South Carolina Gamecocks are averaging 328.5 yards per contest, ranking them 112th in D-1. The South Carolina offense has totaled 633 yds of penalties on 83 infractions, which has them sitting 16th in D-1 in terms of giving up free yards. They hold an average of 117.5 rushing yards per game and have toted the ball for 1,293 yards for the year. They have thrown 9 interceptions while losing 6 fumbles and they have obtained 194 1st downs. In relation to their scoring prowess, the Gamecocks sit 99th in college football with an average of 23.5 points per contest. During the season so far, the Gamecocks have thrown for a total of 2,322 passing yards in addition to holding an average of 211.1 passing yards per game, ranking them 86th in D-1.

South Carolina has allowed the opposition a total of 1,485 yards via the ground game (135.0 yards per game) and 11 touchdowns by way of the ground game this year. They have yielded 13 touchdowns through the air in addition to 211.6 yards per outing, which has them ranked 57th in Division 1. In total, they have relinquished 237 total points. They have earned 10 fumbles recovered and 11 picks on the year. The Gamecocks defense has taken part in 727 plays, which is 60th in D-1. The Gamecocks are giving up 21.5 points per game, which has them sitting 40th in the country.

Who will win tonight's Tigers/Gamecocks college football game against the spread?

Tony's Pick: Take the Gamecocks -3.0

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