Colorado Buffaloes vs Houston Cougars Prediction, 9/12/2025 College Football Picks, Best Bets & Odds

Game: Colorado Buffaloes vs Houston Cougars

Date: Friday, September 12, 2025

Location: TDECU Stadium in Houston, TX

TV: ESPN/ESPN+

Odds/Point Spread: Cougars (-4.5)

Total/Over-Under: 44.5

TDECU Stadium is the site where the Houston Cougars (2-0) will play the Colorado Buffaloes (1-1) on Friday, September 12, 2025. Colorado opens this game as 4.5-point dogs. The over/under is 44.5.

The Colorado Buffaloes come into this game with a record of 1-1 for this year. The last time they took the field, the Buffaloes faced the Delaware Fightin' Blue Hens and walked away with a win by a score of 31-7. In all, they had 70 plays for 398 yds. The Colorado Buffaloes ran the ball 39 different times and tallied 131 yards, which earned them an average of 3.4 yards per attempt. Against the run, the Buffaloes gave up 84 yds on 30 attempts, which averages out to 2.8 yards per run allowed. Colorado gave up 18 pass completions on 36 tries for 312 yds, and a completion rate of 50.0%.

The Buffaloes have racked up 703 total yards for the year. When it comes to distribution of touchdowns, Colorado has totaled 3 touchdowns through the air and 3 touchdowns via the ground. They have yet to turn the ball over. Colorado has amassed 40 first downs as an offense, and they have been called for 9 infractions for 85 yards. Offensively they are averaging 138.5 yards in the run game which is 89th in the country. Regarding getting in the endzone, the Colorado Buffaloes have an average of 25.5 PPG.

The Buffaloes sit in 59th in the country regarding team defense, giving up 17.0 points per game. Opposing teams are running for an average of 5.2 yards per rush and 202.0 rushing yards per contest this season. For the season, they have conceded 404 running yards through 2 games. Concerning passing yards, the Buffaloes are allowing 455 yds which has them ranked 90th in D-1. They are allowing 227.5 yards per outing through the air and giving up a completion percentage of 54.4%. In total, they have surrendered 429.5 yards/game which has them sitting 116th in Division 1. They have yielded 1 touchdown through the air as well as 3 touchdowns running the ball.

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The Cougars head into this game 2-0 for this season. When they last stepped on the gridiron, the Cougars got the victory with a final of 35-9 when they faced the Rice Owls. Houston rushed the ball for 5.4 yards per attempt, totaling 204 yds on 38 carries. The Cougars finished the game with 392 yards on 60 plays (6.5 yds per play). The Cougars secondary gave up a completion rate of 84.6%, relinquishing 51 yds on 11 out of 13 through the air. Houston gave up 53 running attempts for 177 yds (3.3 yards per carry).

In terms of their ability to score points, the Cougars currently sit 56th in the country averaging 31.0 points per outing. The Houston Cougars maintain an average of 367.5 yards/contest, which has them sitting 81st in D-1. The Houston offense has 88 yards of penalties on 10 violations, ranking them 88th in the nation in terms of hurting your team. They have earned 32 1st downs. For the year to this point, the Cougars have thrown for a total of 340 yards through the air as well as holding an average of 170.0 passing yards per contest, which has them ranked 104th in the nation. They have an average of 197.5 rushing yards per game and have run for 395 yards overall.

The Cougars are giving up 4.5 points per game, which has them ranked 5th in D-1. Houston has conceded a total of 216 yards on the ground (108.0 yards per outing) and 1 touchdown by way of the ground game this season. They have yielded 0 touchdowns via the pass and 78.0 yards/game, which has them ranked 3rd in college football. The Cougars defense has participated in 124 plays, which is 48th in the country. Their defense has tallied 1 fumble recovery and 3 picks on the season.

Who will win tonight's Buffaloes/Cougars college football game against the spread?

Guy's Pick: Take the Cougars -4.5

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