Colorado Buffaloes vs TCU Horned Frogs Prediction, 10/4/2025 College Football Picks, Best Bets & Odds

Game: Colorado Buffaloes vs TCU Horned Frogs

Date: Saturday, October 4, 2025

Location: Amon G. Carter Stadium in Fort Worth, TX

TV: FOX

Odds/Point Spread: Horned Frogs (-14.0)

Total/Over-Under: 58.5

Amon G. Carter Stadium is where the TCU Horned Frogs (3-1) will play the Colorado Buffaloes (2-3) on Saturday, October 4, 2025. TCU opens this contest as 14.0-point favorites from oddsmakers. The total is 58.5.

The Colorado Buffaloes come into this matchup with a record of 2-3 this season. The last time they stepped onto the field, the Buffaloes went up against the BYU Cougars and ended up losing by a score of 24-21. The Colorado Buffaloes ran the ball a total of 37 different times and totaled 172 yards, which had them averaging 4.6 yds per attempt. Overall, they tallied 53 plays which gave them 291 yards. Colorado conceded 19 pass completions on 29 attempts for 179 yds, and a completion percentage of 65.5%. In the running game, the Buffaloes conceded 208 yds on 36 attempts, which is an average of 5.8 yards per run surrendered.

The Buffaloes have earned 1,791 total yards for this campaign. When it comes to distribution of touchdowns, Colorado has totaled 8 touchdowns via the pass and 9 rushing touchdowns. They have turned the football over 4 different times. Colorado has accrued 95 first downs as an offense, and they have been flagged for 26 infractions for 250 yards. As a unit they're averaging 147.4 yards rushing giving them a rank of 85th in the country. When it comes to scoring points, the Colorado Buffaloes have an average of 25.8 points per game.

When talking about passing yards, the Buffaloes have given up 1,038 yds which puts them in 82nd in Division 1. They have relinquished 207.6 yards per outing through the air in addition to giving up a completion percentage of 56.6%. During the season, they have surrendered 404.8 yards/contest putting them 111th in the country. They have relinquished 5 touchdowns through the air as well as 7 touchdowns on the ground. They are giving up an average of 4.8 yards per rush and 197.2 rushing yards per contest on the season. Overall, they have allowed 986 rushing yards through 5 outings. The Buffaloes rank 62nd in D-1 when it comes to team defense, allowing 22.8 PPG.

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The Horned Frogs come into this game with a record of 3-1 for this season. When they last stepped on the gridiron, the Horned Frogs walked away with a loss by a score of 27-24 against the Arizona State Sun Devils. TCU gave up 44 running attempts for 201 yards (4.6 yds per carry). The Horned Frogs passing defense conceded a completion rate of 69.2%, relinquishing 291 yards on 27 out of 39 passing. The Horned Frogs finished the contest with a total of 269 yards on 58 plays (4.6 yds per play). TCU rushed the football for 0.4 yards per tote, totaling 10 yards on 25 carries.

When discussing their ability to score points, the Horned Frogs are ranking 30th in Division 1 holding an average of 37.3 points per game. The TCU Horned Frogs maintain an average of 454.3 yards/game, which ranks them 27th in the nation. The TCU offense has totaled 241 yards of penalties on 26 violations, ranking them 73rd in the country in terms of hurting your team. They have thrown 5 picks while allowing opponents to recover 1 fumble and they have been able to earn 92 first downs. Over the course of the season thus far, the Horned Frogs have racked up 1,283 yards via the pass as well as holding an average of 320.8 passing yards per outing, ranking them 12th in college football. They are averaging 133.5 yards via the ground game and have rushed for 534 yards in total.

TCU has conceded a total of 522 yards via the ground game (130.5 yards per outing) and 3 touchdowns via the rush on the season. They have given up 8 touchdowns through the air as well as 257.3 yards per game, which has them sitting 112th in college football. Overall, they have allowed 86 points. Their defense has compiled 3 fumbles and 3 picks so far this year. The Horned Frogs defense has been on the field for 272 plays, which is good for 46th in the nation. The Horned Frogs are allowing 21.5 points per game, ranking them 55th in D-1.

Who will win tonight's Buffaloes/Horned Frogs college football game against the spread?

Tony's Pick: Take the Horned Frogs -14.0

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