Colorado State Rams vs Wyoming Cowboys Prediction, 10/25/2025 College Football Picks, Best Bets & Odds

Game: Colorado State Rams vs Wyoming Cowboys

Date: Saturday, October 25, 2025

Location: War Memorial Stadium in Laramie, WY

TV: CBSSN

Odds/Point Spread: Cowboys (-6.0)

Total/Over-Under: 46.5

The Wyoming Cowboys (3-4) are welcoming the Colorado State Rams (2-5) at War Memorial Stadium on Saturday, October 25, 2025. Colorado State opens this game as 6.0-point underdogs from Vegas oddsmakers. The total comes in at 46.5.

The Colorado State Rams head into this game 2-5 for this season. In their last matchup, the Rams played the Hawaii Warriors and ended up losing by a score of 31-19. The Colorado State Rams ran the football 34 different times and accumulated 85 yds, earning them an average of 2.5 yds per carry. At the end of the game, they tallied 63 plays which gave them 261 yds. Colorado State conceded 26 pass completions on 38 tries for 301 yards, and a completion rate of 68.4%. In the running game, the Rams gave up 134 yards on 28 tries, which is an average of 4.8 yds per rush allowed.

In terms of putting points on the board, the Colorado State Rams have an average of 21.9 points per game. As a unit they're maintaining an average of 148.3 yards on the ground which is 76th in Division 1. The Rams have earned 2,327 total yards for this campaign. In terms of scoring touchdowns, Colorado State has earned 8 passing touchdowns and 11 touchdowns on the ground. Colorado State has accounted for 136 first downs as an offense, and they have committed 46 penalties for 440 yards. They have given the ball to the opposition 8 times.

When talking about yards via the pass, the Rams have allowed 1,658 yards which has them ranked 98th in college football. They have yielded 236.9 yards per contest via the pass and giving up a completion percentage of 62.7%. In total, they have allowed 409.7 yards per outing which ranks them 110th in college football. They have granted 12 touchdowns via the pass as well as 12 touchdowns on the ground. They are allowing teams to run for an average of 4.7 yards per attempt on the ground and 172.9 yards on the ground per game so far this season. Over the course of this year, they have conceded 1,210 rushing yards through 7 games. The Rams are sitting in 89th in Division 1 regarding team defense, giving up 27.0 points per game.

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The Cowboys step onto the field holding a record of 3-4 for this season. The last time they took the field, the Cowboys went home defeated by a final of 24-21 when they played the Air Force Falcons. Wyoming ended up running for 5.5 yds per attempt, totaling 198 yards on 36 attempts. The Cowboys finished with 409 yds on 66 plays (6.2 yards per play). The Cowboys passing defense conceded a completion percentage of 37.5%, relinquishing 33 yds on 3 out of 8 passing. Wyoming conceded 56 attempts on the ground for 330 yds (5.9 yards per rush).

When looking at putting points on the board, the Cowboys sit 116th in the country scoring 20.0 points per contest. The Wyoming Cowboys maintain an average of 365.0 yards/outing, which has them sitting 88th in the country. The Wyoming offense has accrued 401 penalty yards on 46 violations, which ranks them 52nd in college football in terms of making mistakes. They have given away 7 interceptions while losing 5 fumbles and they have been able to earn 145 first downs. During this campaign so far, the Cowboys currently sit at 1,509 yards through the air as well as an average of 215.6 throwing yards per outing, which is ranked 87th in D-1. They hold an average of 149.4 yards via the ground game and have rushed for 1,046 yards for this season.

Wyoming has surrendered a total of 1,178 rushing yards (168.3 yards per outing) and 8 touchdowns rushing for the year. They have surrendered 10 touchdowns through the air and 179.9 yards per game, which has them ranked 26th in D-1. In total, they have relinquished 158 points. Their defense has compiled 4 fumbles and 4 interceptions on the season. The Cowboys defense has taken the field for 476 plays, which is good for 90th in the country. The Cowboys are relinquishing 22.6 PPG, which has them 54th in the country.

Who will win tonight's Rams/Cowboys college football game against the spread?

Josh's Pick: Take the Rams +6.0

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