Duke Blue Devils vs Clemson Tigers Prediction, 11/1/2025 College Football Picks, Best Bets & Odds

Game: Duke Blue Devils vs Clemson Tigers

Date: Saturday, November 1, 2025

Location: Memorial Stadium in Clemson, SC

TV: ACC Network

Odds/Point Spread: Tigers (-3.5)

Total/Over-Under: 56

The Duke Blue Devils (4-3) are en route to Memorial Stadium on Saturday, November 1, 2025 where they will play the Clemson Tigers (3-4). Clemson opens this matchup as 3.5-point favorites. The total is 56.

The Duke Blue Devils come into this matchup with a record of 4-3 for this season. The last time they stepped onto the field, the Blue Devils played against the Georgia Tech Yellow Jackets and walked away from this one with a loss by a score of 27-18. When the final whistle blew, they had 76 plays for 441 yds. The Duke Blue Devils ran the rock 32 different times and accumulated 68 yards, earning them an average of 2.1 yds per carry. In the running game, the Blue Devils conceded 171 yards on 36 attempts, which averages out to 4.8 yds per run surrendered. Duke surrendered 14 pass completions on 21 tries for a total of 205 yds, and a completion rate of 66.7%.

Regarding scoring, the Duke Blue Devils have an average of 33.9 points per game. As a unit they maintain an average of 144.3 yards on the ground ranking them 80th in Division 1. The Blue Devils have attained 3,243 total yards this season. When it comes to distribution of touchdowns, Duke has earned 17 touchdowns through the air and 12 touchdowns via the ground. Duke has accumulated 166 1st downs offensively, and they have been flagged for 50 infractions for 499 yds. They have turned the ball over 8 times.

The Blue Devils are ranked 82nd in the country when it comes to team defense, conceding 25.7 points per game. They are allowing an average of 3.6 yards per tote and 130.0 yards on the ground per game this year. Over the course of this season, they have allowed 910 yards via the ground game in 7 outings. When talking about yards through the air, the Blue Devils have given up 1,721 yds which ranks them 78th in Division 1. They have allowed 245.9 yards per contest through the air and conceding a completion percentage of 67.6%. Over the course of this season, they have yielded 375.9 yards/game which puts them 77th in the nation. They have yielded 6 touchdowns by air in addition to 16 touchdowns running the ball.

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The Tigers head into this matchup 3-4 for this season. The last time they took the field, the Tigers took a defeat with a final score of 35-24 when they faced the SMU Mustangs. Clemson rushed for 1.2 yards per tote, finishing the game with 35 yards on 30 attempts. The Tigers finished with 352 yds and they ran 72 plays (4.9 yards per play). The Tigers passing defense gave up a completion rate of 53.5%, relinquishing 290 yds on 23 out of 43 through the air. Clemson allowed 28 running attempts for 139 yards (5.0 yards per rush).

Regarding their ability to score points, the Tigers are sitting 79th in Division 1 scoring 26.0 points per contest. The Clemson Tigers hold an average of 400.7 yards per outing, which is good for 60th in Division 1. The Clemson offense has compiled 309 penalty yards on 31 violations, which ranks 130th in the country in terms of hurting your team. They have thrown 6 picks while letting opponents recover 6 fumbles and they have been able to obtain 147 first downs. Over the course of the season thus far, the Tigers have a total of 1,990 passing yards as well as an average of 284.3 passing yards per outing, which is ranked 22nd in D-1. They have an average of 116.4 run yards per game and have run for 815 yards in total.

Clemson has yielded a total of 768 rushing yards (109.7 yards per outing) and 8 touchdowns by way of the ground game this year. They have given up 7 touchdowns from the passing game in addition to 227.9 yards per game, ranking them 78th in Division 1. Overall, they have allowed 146 total points. Their defense has totaled 3 fumbles recovered and 5 interceptions for the season. The Tigers defense has been on the field for 472 plays, which ranks 34th in Division 1. The Tigers are relinquishing 20.9 points per contest, which puts them 38th in college football.

Who will win tonight's Blue Devils/Tigers college football game against the spread?

Tony's Pick: Take the Tigers -3.5

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