Duke Blue Devils vs North Carolina Tar Heels Prediction, 11/22/2025 College Football Picks, Best Bets & Odds

Game: Duke Blue Devils vs North Carolina Tar Heels

Date: Saturday, November 22, 2025

Location: Kenan Stadium in Chapel Hill, NC

TV: ACC Network

Odds/Point Spread: Tar Heels (+7.0)

Total/Over-Under: 51.5

Kenan Stadium is the site where the North Carolina Tar Heels (4-6) will try to defeat the Duke Blue Devils (5-5) on Saturday, November 22, 2025. Duke opens this game as 7.0-point favorites from oddsmakers. The over/under comes in at 51.5.

The Duke Blue Devils head into this game 5-5 for this season. In their last contest, the Blue Devils took on the Virginia Cavaliers and walked away from this one with a loss by a score of 34-17. The Duke Blue Devils ended up running the ball 23 different times and accrued 42 yds, which earned them an average of 1.8 yards per tote. At the end of the game, they ran 58 plays which gave them a total of 255 yds. Duke relinquished 23 pass completions on 35 tries for 316 yds, and a completion percentage of 65.7%. On the ground, the Blue Devils gave up 224 yards on 42 tries, which is an average of 5.3 yards per run surrendered.

The Blue Devils have earned 4,327 total yards for the year. In terms of scoring, Duke has amassed 25 passing touchdowns and 15 rushing touchdowns. They have surrendered the football 12 times. Duke has accrued 225 first downs, and they have been flagged for 68 penalties for 669 yds. As a team they're averaging 129.8 yards on the ground which ranks them 100th in the nation. When it comes to putting the ball in the endzone, the Duke Blue Devils hold an average of 33.4 PPG.

The Blue Devils sit in 104th in D-1 concerning team defense, conceding 29.6 PPG. They are allowing an average of 4.1 yards per attempt on the ground and 146.5 yards on the ground per game for the year. During this campaign, they have allowed 1,465 rushing yards through 10 contests. When talking about yards through the air, the Blue Devils have conceded 2,738 yds which ranks them 128th in the country. They have yielded 273.8 yards per contest through the air and conceding a completion percentage of 68.3%. Over the course of this year, they are giving up 420.3 yards per game which has them sitting 119th in college football. They have granted 13 touchdowns through the air as well as 23 touchdowns running the ball.

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The Tar Heels step onto the field holding a record of 4-6 for this season. For their last game, the Tar Heels took a loss by a score of 28-12 when they played the Wake Forest Demon Deacons. North Carolina gave up 35 running attempts for 36 yds (1.0 yds per carry). The Tar Heels secondary gave up a completion percentage of 69.2%, surrendering 284 yards on 27 for 39 passing. The Tar Heels finished the game with 257 yds while running 61 plays (4.2 yds per play). North Carolina rushed the football for 2.3 yds per attempt, totaling 56 yards on 24 attempts.

Regarding putting points on the board, the Tar Heels rank 123rd in college football by scoring 18.7 points per game. The North Carolina Tar Heels hold an average of 289.5 yards/game, which ranks them 131st in college football. The North Carolina offense has 519 penalty yds on 56 infractions, which is good for 98th in the country in terms of giving up free yards. They have tossed 6 picks while losing 8 fumbles and they have been able to earn 161 first downs. During this campaign thus far, the Tar Heels have thrown for 1,803 passing yards as well as an average of 180.3 throwing yards per contest, putting them at 113th in college football. They are averaging 109.2 run yards per game and have run for 1,092 yards for the year.

The Tar Heels are conceding 22.0 points per contest, which has them ranked 43rd in the nation. North Carolina has allowed a total of 1,146 yards on the ground (114.6 yards/game) as well as 12 touchdowns by way of the ground game so far this year. They have allowed the opposition 12 touchdowns through the air as well as 215.9 yards per game, ranking them 61st in the nation. The Tar Heels defense has been on the field for 670 plays, which is 72nd in Division 1. They have compiled 6 fumbles recovered and 6 picks over the course of the season. Overall, they have given up 220 pts.

Who will win tonight's Blue Devils/Tar Heels college football game against the spread?

Josh's Pick: Take the Tar Heels +7.0

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