East Carolina Pirates vs UTSA Roadrunners Prediction, 11/22/2025 College Football Picks, Best Bets & Odds

Game: East Carolina Pirates vs UTSA Roadrunners

Date: Saturday, November 22, 2025

Location: Alamodome in San Antonio, TX

TV: ESPN+

Odds/Point Spread: Roadrunners (+2.5)

Total/Over-Under: 62.5

The East Carolina Pirates (7-3) are traveling to Alamodome on Saturday, November 22, 2025 where they will play the UTSA Roadrunners (5-5). East Carolina opens as 2.5-point favorites. The total is 62.5.

The East Carolina Pirates come into this matchup with a record of 7-3 this season. In their last game, the Pirates stepped onto the field against the Memphis Tigers and earned the victory with a final of 31-27. Against the run, the Pirates gave up 240 yards on 33 attempts, which averages out to 7.3 yards per run surrendered. East Carolina conceded 33 completions on 44 tries for a total of 217 yds, and a completion percentage of 75.0%. At the end of the game, they ran 72 plays which gave them 454 yds. The East Carolina Pirates ran the ball 38 times and totaled 122 yards, earning them an average of 3.2 yards per attempt.

The Pirates have earned 4,663 total yards for the season. With reference to getting the ball in the endzone, East Carolina has earned 16 passing touchdowns and 26 touchdowns on the ground. They have turned the ball over 9 different times. East Carolina has amassed 249 first downs as a team, and they have been called for 66 penalties for 552 yds. As a team they're averaging 179.6 yards on the ground giving them a rank of 40th in Division 1. Concerning putting the ball in the endzone, the East Carolina Pirates are sitting at 33.6 points per outing.

The Pirates rank 16th in college football when it comes to the opposition scoring, giving up 18.3 PPG. They are allowing teams to run for an average of 3.6 yards per rushing attempt and 119.4 rushing yards per contest on the year. Overall, they have given up 1,194 rushing yards through 10 contests. In terms of yards through the air, the Pirates have conceded 2,197 yds which has them sitting in 66th in Division 1. They have allowed 219.7 yards per game through the air as well as conceding a completion percentage of 63.0%. For the season, they have given up 339.1 yards per game which has them ranked 43rd in D-1. They have relinquished 10 touchdowns by air in addition to 10 touchdowns running the ball.

Get all of our College Football Picks

The Roadrunners come into this game with a record of 5-5 for this season. In their last game, the Roadrunners got the victory with a final of 28-7 against the Charlotte 49ers. UTSA surrendered 32 rushing attempts for 238 yds (7.4 yds per carry). The Roadrunners pass defense allowed a completion rate of 88.9%, surrendering 233 yds on 16 for 18 passing. The Roadrunners finished the contest with a total of 521 yards on 75 plays (6.9 yards per play). UTSA ran for 5.7 yards per attempt, finishing the contest with 215 yards on 38 carries.

In relation to their ability to score points, the Roadrunners currently rank 38th in college football averaging 32.3 PPG. The UTSA Roadrunners are averaging 411.9 yards per game, which is good for 48th in the nation. The UTSA offense has compiled 672 yards of penalties on 72 infractions, which ranks 27th in college football in terms of giving up free yards. They have given away 6 picks while losing 5 fumbles and they have earned 213 first downs. During the season so far, the Roadrunners have thrown for 2,406 passing yards together with holding an average of 240.6 passing yards per game, putting them at 58th in D-1. They average 171.3 rushing yards per game and have run for 1,713 yards in total.

UTSA has allowed a total of 1,475 yards rushing (147.5 yards/game) and 14 touchdowns by way of the ground game this season. They have allowed 21 touchdowns via the pass as well as 240.6 yards/game, which has them sitting 98th in college football. Over the course of the season, they have conceded 304 points in total. They have 5 fumbles and 8 interceptions on the campaign. The Roadrunners defense has taken the field for 648 plays, which has them ranked 42nd in the country. The Roadrunners are conceding 30.4 points per game, ranking them 111th in the nation.

Who will win tonight's Pirates/Roadrunners college football game against the spread?

Josh's Pick: Take the Pirates -2.5

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get college football picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.