Houston Cougars vs Oklahoma State Cowboys Prediction, 10/11/2025 College Football Picks, Best Bets & Odds

Game: Houston Cougars vs Oklahoma State Cowboys

Date: Saturday, October 11, 2025

Location: Boone Pickens Stadium in Stillwater, OK

TV: TNT

Odds/Point Spread: Cowboys (+13.5)

Total/Over-Under: 47.5

The Oklahoma State Cowboys (1-4) will compete against the Houston Cougars (4-1) at Boone Pickens Stadium on Saturday, October 11, 2025. Oklahoma State opens as 13.5-point dogs from Vegas oddsmakers. The total is 47.5.

The Houston Cougars come into this matchup with a record of 4-1 this year. In their last contest, the Cougars stepped onto the field against the Texas Tech Red Raiders and took a loss by a final of 35-11. Against the run, the Cougars conceded 207 yards on 50 attempts, which averages out to 4.1 yards per run surrendered. Houston gave up 28 completions on 40 tries for 345 yards, and a completion rate of 70.0%. When the final whistle blew, they ran 55 plays for 267 yds. The Houston Cougars rushed the ball a total of 30 times and recorded 103 yards, which is an average of 3.4 yds per attempt.

The Cougars have racked up 1,785 yards in total over the course of this year. In terms of getting in the endzone, Houston has earned 7 touchdowns through the air and 7 touchdowns on the ground. They have given the ball to the opposition 4 different times. Houston has accrued 82 1st downs offensively, and they have committed 27 penalties for 238 yds. Offensively they're averaging 157.8 yards on the ground which has them sitting 66th in college football. Concerning getting in the endzone, the Houston Cougars are averaging 27.2 points per game.

In terms of passing yardage, the Cougars are giving up 906 yards which ranks them 32nd in college football. They have surrendered 181.2 yards per outing through the air as well as allowing a completion percentage of 61.7%. For the year, they have allowed 322.8 yards per game putting them at 43rd in college football. They have relinquished 3 touchdowns by air in addition to 7 touchdowns on the ground. They are allowing an average of 3.5 yards per rush on the ground and 141.6 rushing yards per game on the year. During this campaign, they have conceded 708 yards via the running game in 5 games. The Cougars are ranked 29th in Division 1 regarding their opponents scoring, conceding 17.6 points per contest.

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The Cowboys head into this matchup 1-4 for this season. When they last stepped on the gridiron, the Cowboys took a loss by a final score of 41-13 against the Arizona Wildcats. Oklahoma State rushed the ball for 2.9 yds per attempt, finishing the contest with 89 yds on 31 attempts. The Cowboys finished the game with 158 yds while they ran 59 plays (2.7 yds per play). The Cowboys secondary conceded a completion percentage of 72.1%, relinquishing 433 yds on 31 for 43 through the air. Oklahoma State conceded 33 rushing attempts for 45 yards (1.4 yds per carry).

Concerning their ability to score points, the Cowboys are sitting 130th in the country averaging 16.4 PPG. The Oklahoma State Cowboys average 315.8 yards per contest, which is good for 122nd in D-1. The Oklahoma State offense has 275 yds of penalties on 28 violations, which has them sitting 98th in college football in terms of helping out the other team. They have thrown 3 interceptions while surrendering 1 fumble and they have tallied 82 first downs. For the season thus far, the Cowboys have thrown for a total of 877 yards via the pass as well as holding an average of 175.4 passing yards per game, ranking them 113th in D-1. They maintain an average of 140.4 yards per game via the ground game and have rushed for 702 yards for this season.

The Cowboys are conceding 36.2 points per game, which has them sitting 130th in D-1. Oklahoma State has surrendered a total of 897 yards rushing (179.4 yards per outing) and 7 touchdowns via the rush so far this year. They have allowed 14 touchdowns via the pass and 294.6 yards/contest, which has them sitting 132nd in the country. The Cowboys defense has been on the field for 346 plays, ranking them 80th in the nation. Their defense has 3 fumbles and 3 interceptions this year. This season, they have conceded 181 total points.

Who will win tonight's Cougars/Cowboys college football game against the spread?

Guy's Pick: Take the Cowboys +13.5

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