Indiana Hoosiers vs Iowa Hawkeyes Prediction, 9/27/2025 College Football Picks, Best Bets & Odds

Game: Indiana Hoosiers vs Iowa Hawkeyes

Date: Saturday, September 27, 2025

Location: Kinnick Stadium in Iowa City, IA

TV: Peacock

Odds/Point Spread: Hawkeyes (+7.0)

Total/Over-Under: 48

The Iowa Hawkeyes (3-1) welcome the Indiana Hoosiers (4-0) at Kinnick Stadium on Saturday, September 27, 2025. Indiana is 7.0-point favorites. The betting total comes in at 48.

The Indiana Hoosiers step onto the field holding a record of 4-0 for this year. The last time they took the field, the Hoosiers faced the Illinois Fighting Illini and earned the victory with a final of 63-10. When it came to the battle of the line of scrimmage, the Hoosiers conceded 2 yards on 20 attempts, which averages out to 0.1 yards per run allowed. Indiana relinquished 16 pass completions on 25 tries for 159 yards, and a completion percentage of 64.0%. In the game, they had 72 plays for 579 yds. The Indiana Hoosiers ran the football 49 different times and totaled 312 yards, which earned them an average of 6.4 yds per carry.

The Hoosiers have racked up 2,354 total yards over the course of this year. When it comes to distribution of touchdowns, Indiana has compiled 17 touchdowns through the air and 11 rushing touchdowns. They have turned the football over 1 time. Indiana has accounted for 122 first downs as a team, and they have been hurt by 15 penalties for 120 yards. As a team they are averaging 308.8 yards in the run game ranking them 3rd in Division 1. Regarding putting the ball in the endzone, the Indiana Hoosiers hold an average of 54.8 points per contest.

The Hoosiers rank 5th in the nation in terms of the opposition scoring, conceding 8.3 PPG. Opposing teams are running for an average of 3.3 yards per rush and 87.0 rushing yards per game for the year. Overall, they have given up 348 rushing yards through 4 games. Regarding yards through the air, the Hoosiers are giving up 475 yards which ranks them 13th in college football. They are allowing 118.8 yards per outing through the air in addition to allowing a completion percentage of 58.2%. Over the course of this year, they are granting 205.8 yards per game which puts them 3rd in D-1. They have granted 1 touchdown by air as well as 2 touchdowns via the ground game.

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The Hawkeyes come into this game with a record of 3-1 this season. When they last stepped on the gridiron, the Hawkeyes took home the win by a final score of 38-28 when they faced the Rutgers Scarlet Knights. The Hawkeyes finished the game with a total of 346 yds while running 56 plays (6.2 yards per play). Iowa ran the ball for 4.2 yds per carry, finishing the game with 160 yds on 38 carries. Iowa gave up 30 attempts on the ground for 70 yards (2.3 yds per rush). The Hawkeyes passing defense gave up a completion rate of 60.0%, surrendering 330 yards on 24 for 40 through the air.

Concerning putting points on the board, the Hawkeyes currently rank 54th in D-1 averaging 33.0 PPG. The Iowa Hawkeyes hold an average of 338.3 yards/game, ranking them 106th in D-1. The Iowa offense has compiled 93 yards of penalties on 9 infractions, which ranks 134th in college football in terms of helping out the other team. They have thrown 1 picks while conceding 1 fumble and they have been able to obtain 80 1st downs. During this campaign so far, the Hawkeyes have earned 551 passing yards as well as an average of 137.8 passing yards per game, ranking them 129th in the country. They maintain an average of 200.5 run yards per game and have toted the ball for 802 yards for this season.

The Hawkeyes are giving up 14.5 PPG, which puts them 24th in Division 1. Iowa has allowed a total of 243 rushing yards (60.8 yards per contest) in addition to 5 touchdowns via the rush on the season. They have allowed the opposition 2 touchdowns from the passing game and 172.8 yards/outing, which has them ranked 32nd in the nation. The Hawkeyes defense has participated in 223 plays, which is 42nd in D-1. Their defense has totaled 1 fumble and 1 interception so far this year. Overall, they have conceded 58 points.

Who will win tonight's Hoosiers/Hawkeyes college football game against the spread?

Guy's Pick: Take the Hoosiers -7.0

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