Indiana Hoosiers vs Ohio State Buckeyes Prediction, 12/6/2025 College Football Picks, Best Bets & Odds

Game: Indiana Hoosiers vs Ohio State Buckeyes

Date: Saturday, December 6, 2025

Location: Lucas Oil Stadium in Indianapolis, IN

TV: FOX

Odds/Point Spread: Buckeyes (-4.0)

Total/Over-Under: 47.5

Lucas Oil Stadium is the site where the Ohio State Buckeyes (12-0) will play the Indiana Hoosiers (12-0) on Saturday, December 6, 2025 in the Big Ten Championship. Indiana opens this game as 4.0-point underdogs. The total comes in at 47.5.

The Indiana Hoosiers head into this matchup 12-0 for this season. In their last game, the Hoosiers played the Purdue Boilermakers and walked away with a win by a score of 56-3. In the running game, the Hoosiers gave up 44 yards on 27 tries, which is an average of 1.6 yards per rush surrendered. Indiana gave up 25 pass completions on 47 tries for 238 yds, and a completion rate of 53.2%. At the end of the game, they tallied 54 plays which gave them 548 yards. The Indiana Hoosiers rushed the ball a total of 37 different times and accounted for 355 yards, which is an average of 9.6 yards per tote.

The Hoosiers have racked up 5,806 yards in total this season. When it comes to getting in the endzone, Indiana has earned 37 passing touchdowns and 29 touchdowns via the ground. They have turned the ball over 7 different times. Indiana has earned 304 first downs as a unit, and they have been called for 44 infractions for 322 yards. As a team they maintain an average of 229.8 yards via the ground game which has them sitting 9th in college football. Regarding putting points on the board, the Indiana Hoosiers have an average of 44.3 PPG.

The Hoosiers rank 2nd in the country concerning their opponents scoring, conceding 10.9 points per game. The opposition is running for an average of 2.9 yards per attempt on the ground and 79.3 rushing yards per contest on the season. For the year, they have allowed 952 rushing yards through 12 contests. Concerning yards via the pass, the Hoosiers are conceding 2,070 yards which has them sitting in 14th in Division 1. They have surrendered 172.5 yards per game via the pass in addition to allowing a completion percentage of 60.8%. Over the course of this season, they have surrendered 251.8 yards per game which has them sitting 4th in college football. They have allowed 6 touchdowns by air and 5 touchdowns via the ground game.

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The Buckeyes come into this game with a record of 12-0 for this season. For their last game, the Buckeyes got the victory with a final of 27-9 when they faced the Michigan Wolverines. The Buckeyes finished the contest with a total of 419 yards and they ran 73 plays (5.7 yards per play). Ohio State rushed the football for 4.0 yards per attempt, finishing the contest with 186 yards on 47 attempts. Ohio State allowed 24 rushing attempts for 100 yards (4.2 yds per rush). The Buckeyes secondary gave up a completion percentage of 44.4%, surrendering 63 yards on 8 for 18 passing.

When it comes to how much they score, the Buckeyes currently rank 13th in the nation by scoring 37.0 PPG. The Ohio State Buckeyes are averaging 438.5 yards/game, ranking them 24th in the nation. The Ohio State offense has racked up 509 yards of penalties on 54 infractions, which has them ranked 122nd in the nation in terms of helping out the other team. They have tossed 5 interceptions while losing 4 fumbles and they have been able to obtain 282 first downs. Over the course of the season thus far, the Buckeyes have a total of 3,204 yards via the pass as well as holding an average of 267.0 passing yards per outing, which is ranked 26th in Division 1. They average 171.5 rushing yards per game and have run for 2,058 yards for the season.

Ohio State has allowed a total of 980 yards rushing (81.7 yards/game) and 4 touchdowns via the rush for the season. They have conceded 5 touchdowns from the passing game as well as 121.3 yards/game, which has them sitting 1st in the country. Overall, they have allowed 94 total points. They have compiled 6 fumbles recovered and 7 picks on the year. The Buckeyes defense has taken part in 647 plays, which has them ranked 1st in college football. The Buckeyes are allowing 7.8 points per contest, which has them 1st in Division 1.

Who will win tonight's Hoosiers/Buckeyes college football game against the spread?

Guy's Pick: Take the Buckeyes -4.0

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