Indiana Hoosiers vs Oregon Ducks Prediction, 10/11/2025 College Football Picks, Best Bets & Odds

Game: Indiana Hoosiers vs Oregon Ducks

Date: Saturday, October 11, 2025

Location: Autzen Stadium in Eugene, OR

TV: CBS

Odds/Point Spread: Ducks (-7.5)

Total/Over-Under: 54.5

The Oregon Ducks (5-0) welcome the Indiana Hoosiers (5-0) at Autzen Stadium on Saturday, October 11, 2025. Indiana opens this matchup as 7.5-point underdogs from oddsmakers. The total is 54.5.

The Indiana Hoosiers head into this game 5-0 this season. The last time they stepped onto the field, the Hoosiers faced the Iowa Hawkeyes and went home with a win by a final score of 20-15. When all was said and done, they ran 62 plays which gave them 337 yds. The Indiana Hoosiers ended up running the ball 39 times and tallied 104 yards, earning them an average of 2.7 yards per carry. On the ground, the Hoosiers gave up 92 yds on 31 attempts, which is 3.0 yds per run surrendered. Indiana surrendered 24 completions on 38 tries for a total of 192 yards, and a completion percentage of 63.2%.

The Hoosiers have racked up 2,691 total yards for the season. In terms of getting in the endzone, Indiana has earned 19 passing touchdowns and 11 rushing touchdowns. They have surrendered the football 2 different times. Indiana has a total of 140 1st downs as a unit, and they have been hurt by 19 infractions for 150 yds. As a team they're maintaining an average of 267.8 yards in the run game which is 5th in Division 1. When it comes to putting points on the board, the Indiana Hoosiers are averaging 47.8 points per game.

The Hoosiers are ranked 3rd in the nation in terms of the opposition scoring, allowing 9.6 PPG. They are giving up an average of 3.2 yards per rush and 88.0 rushing yards per game this year. During the season, they have conceded 440 rushing yards through 5 games. Concerning yards through the air, the Hoosiers are conceding 667 yds which ranks them 7th in Division 1. They are giving up 133.4 yards per outing through the air and conceding a completion percentage of 59.5%. Overall, they have given up 221.4 yards/game which has them ranked 5th in the country. They have granted 1 touchdown through the air as well as 3 touchdowns on the ground.

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The Ducks come into this matchup with a record of 5-0 for this season. For their last game, the Ducks went home victorious with a score of 30-24 when they played the Penn State Nittany Lions. The Ducks ended up finishing with 424 yards while they ran 78 plays (5.4 yards per play). Oregon ran for 4.5 yards per tote, finishing with a total of 176 yds on 39 carries. Oregon allowed 35 running attempts for 139 yards (4.0 yards per rush). The Ducks passing defense conceded a completion percentage of 56.0%, relinquishing 137 yds on 14 out of 25 through the air.

In relation to their ability to score points, the Ducks sit 6th in college football holding an average of 46.6 PPG. The Oregon Ducks hold an average of 503.8 yards per contest, which is good for 9th in the nation. The Oregon offense has compiled 138 yards of penalties on 18 infractions, which is 131st in the country in terms of helping out the other team. They have tossed 1 interception while letting opponents recover 0 fumbles and they have been able to record 123 first downs. For the year thus far, the Ducks have earned 1,322 yards through the air not to mention an average of 264.4 throwing yards per game, which ranks 40th in the country. They have an average of 239.4 run yards per game and have toted the ball for 1,197 yards overall.

Oregon has surrendered a total of 574 yards on the ground (114.8 yards per game) and 5 touchdowns via the rush for the campaign. They have conceded 2 touchdowns through the air in addition to 123.4 yards per outing, which has them in 3rd in the nation. This season, they have allowed 61 pts. They have compiled 1 fumble and 5 interceptions so far this year. The Ducks defense has taken the field for 286 plays, which is good for 11th in the nation. The Ducks are allowing 12.2 PPG, which has them sitting 6th in college football.

Who will win tonight's Hoosiers/Ducks college football game against the spread?

Guy's Pick: Take the Ducks -7.5

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