Iowa Hawkeyes vs Iowa State Cyclones Prediction, 9/6/2025 College Football Picks, Best Bets & Odds

Game: Iowa Hawkeyes vs Iowa State Cyclones

Date: Saturday, September 6, 2025

Location: Jack Trice Stadium in Ames, IA

TV: FOX

Odds/Point Spread: Cyclones (-3.0)

Total/Over-Under: 41.5

Jack Trice Stadium is the location where the Iowa State Cyclones (2-0) will take on the Iowa Hawkeyes (1-0) on Saturday, September 6, 2025. Iowa opens this matchup as 3.0-point underdogs from Vegas oddsmakers. The total comes in at 41.5.

The Iowa Hawkeyes come into this game with a record of 1-0 for this year. In their last contest, the Hawkeyes stepped onto the field against the Albany Great Danes and went home with a win by a final score of 34-7. In all, they ran 69 plays which gave them 358 yds. The Iowa Hawkeyes ran the football 53 different times and accumulated 310 yards, which came out to an average of 5.8 yards per tote. On the ground, the Hawkeyes conceded 43 yds on 21 attempts, which is an average of 2.0 yds per run surrendered. Iowa surrendered 13 pass completions on 26 tries for a total of 134 yards, and a completion percentage of 50.0%.

The Hawkeyes have tallied 358 total yards for the year. With reference to getting the ball in the endzone, Iowa has earned 1 touchdown through the air and 3 touchdowns on the ground. They have turned the ball over 1 time. Iowa has earned 20 1st downs as an offense, and they have been flagged for 2 infractions for 20 yds. As a team they're maintaining an average of 310.0 yards on the ground ranking this team at 8th in college football. When talking about scoring, the Iowa Hawkeyes are averaging 34.0 PPG.

When it comes to passing yards, the Hawkeyes have conceded 134 yards which puts them in 36th in college football. They are giving up 134.0 yards per contest via the pass in addition to conceding a completion percentage of 50.0%. Overall, they have yielded 177.0 yards/contest putting them 17th in the country. They have relinquished 1 touchdown through the air. Opposing teams are running for an average of 2.0 yards per run and 43.0 yards on the ground per contest on the year. For the season, they have allowed 43 yards on the ground through 1 outing. The Hawkeyes are sitting in 31st in D-1 in terms of the opposition scoring, conceding 7.0 PPG.

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The Cyclones head into this matchup 2-0 for this season. When they last stepped on the gridiron, the Cyclones walked away with a victory by a final of 55-7 when they played the South Dakota Coyotes. Iowa State relinquished 22 rush attempts for 83 yds (3.8 yds per carry). The Cyclones secondary gave up a completion rate of 51.7%, relinquishing 126 yds on 15 for 29 through the air. The Cyclones finished the game with a total of 529 yds while running 67 plays (7.9 yds per play). Iowa State ran the ball for 5.3 yards per tote, finishing with 223 yds on 42 attempts.

Regarding the points being put on the board, the Cyclones are 38th in the country by tallying 39.5 points per game. The Iowa State Cyclones maintain an average of 421.0 yards per outing, which is good for 56th in Division 1. The Iowa State offense has racked up 35 penalty yards on 4 violations, which is 102nd in Division 1 in terms of giving up free yards. They have recorded 47 first downs. During this campaign thus far, the Cyclones have thrown for 489 yards through the air as well as holding an average of 244.5 passing yards per outing, giving them a rank of 53rd in D-1. They maintain an average of 176.5 rushing yards per game.

The Cyclones are giving up 14.0 PPG, which has them ranked 61st in Division 1. Iowa State has given up a total of 193 yards rushing. They have given up 3 touchdowns via the pass in addition to 199.5 yards/contest, which has them sitting 81st in the country. The Cyclones defense has been on the field for 108 plays, which is good for 131st in the country. Their defense has compiled 2 fumbles and 2 picks on the year.

Who will win tonight's Hawkeyes/Cyclones college football game against the spread?

Guy's Pick: Take the Cyclones -3.0

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