Iowa Hawkeyes vs USC Trojans Prediction, 11/15/2025 College Football Picks, Best Bets & Odds

Game: Iowa Hawkeyes vs USC Trojans

Date: Saturday, November 15, 2025

Location: Los Angeles Memorial Coliseum in Los Angeles, CA

TV: BTN

Odds/Point Spread: Trojans (-6.0)

Total/Over-Under: 49.5

Los Angeles Memorial Coliseum is the site where the USC Trojans (7-2) will take on the Iowa Hawkeyes (6-2) on Saturday, November 15, 2025. USC opens this game as 6.0-point favorites. The over/under is set at 49.5.

The Iowa Hawkeyes come into this matchup with a record of 6-2 for this year. In their last game, the Hawkeyes faced off with the Oregon Ducks and took a loss by a score of 18-16. At the end of the game, they had 61 plays which totaled 239 yards. The Iowa Hawkeyes ran the ball a total of 43 times and tallied 101 yards, earning them an average of 2.3 yards per carry. When it came to the battle of the line of scrimmage, the Hawkeyes gave up 261 yds on 36 attempts, which calculates to 7.3 yards per rush surrendered. Iowa allowed 13 pass completions on 21 attempts for 112 yards, and a completion rate of 61.9%.

The Hawkeyes have tallied 2,543 yards in total over the course of this year. When it comes to scoring touchdowns, Iowa has totaled 5 touchdowns through the air and 20 touchdowns on the ground. They have turned the football over 6 different times. Iowa has earned 139 1st downs as a unit, and they have been called for 19 penalties for 183 yards. As a unit they're averaging 185.3 yards in the run game which ranks them 37th in college football. When it comes to putting points on the board, the Iowa Hawkeyes are sitting at 31.3 points per game.

When talking about passing yards, the Hawkeyes are giving up 1,208 yds which ranks them 4th in the country. They are giving up 151.0 yards per outing through the air as well as conceding a completion percentage of 55.8%. For the season, they have yielded 234.9 yards/contest which ranks them 3rd in the nation. They have granted 4 touchdowns through the air in addition to 7 touchdowns via the ground game. They are allowing teams to run for an average of 2.6 yards per tote and 83.9 rushing yards per contest for the season. Overall, they have allowed 671 rushing yards through 8 games. The Hawkeyes sit in 4th in college football when it comes to team defense, giving up 13.1 PPG.

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The Trojans head into this matchup 7-2 this season. In their last game, the Trojans walked away with a victory by a final of 38-17 against the Northwestern Wildcats. USC allowed 25 attempts on the ground for 130 yds (5.2 yds per carry). The Trojans passing defense allowed a completion percentage of 66.7%, surrendering 150 yards on 20 out of 30 through the air. The Trojans finished the game with 482 yards on 64 plays (7.5 yards per play). USC ran the football for 5.8 yds per attempt, finishing with 173 yards on 30 carries.

When it comes to this team's ability to score points, the Trojans rank 9th in Division 1 holding an average of 39.6 points per game. The USC Trojans maintain an average of 503.2 yards/contest, which has them sitting 4th in the nation. The USC offense has totaled 507 yards of penalties on 57 infractions, which is 52nd in the country in terms of helping out the opposition. They have tossed 6 picks while letting opponents recover 6 fumbles and they have obtained 224 1st downs. Over the course of the season so far, the Trojans have thrown for a total of 2,727 passing yards not to mention an average of 303.0 passing yards per outing, ranking them 9th in Division 1. They are averaging 200.2 yards per game via the rush and have toted the ball for 1,802 yards for this year.

The Trojans are giving up 21.8 PPG, ranking them 42nd in Division 1. USC has yielded a total of 1,275 yards via the ground game (141.7 yards/game) as well as 8 touchdowns rushing so far this year. They have allowed 16 touchdowns through the air and 205.1 yards/game, which has them ranked 50th in college football. The Trojans defense has taken part in 563 plays, which ranks them 63rd in the country. Their defense has compiled 6 fumbles and 9 picks for the year. In total, they have given up 196 points in total.

Who will win tonight's Hawkeyes/Trojans college football game against the spread?

Tony's Pick: Take the Hawkeyes +6.0

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