Iowa State Cyclones vs Colorado Buffaloes Prediction, 10/11/2025 College Football Picks, Best Bets & Odds

Game: Iowa State Cyclones vs Colorado Buffaloes

Date: Saturday, October 11, 2025

Location: Folsom Field in Boulder, CO

TV: ESPN

Odds/Point Spread: Buffaloes (+4.0)

Total/Over-Under: 53

Folsom Field is where the Colorado Buffaloes (2-4) will compete against the Iowa State Cyclones (5-1) on Saturday, October 11, 2025. Iowa State opens this contest as 4.0-point favorites from Vegas oddsmakers. The betting total comes in at 53.

The Iowa State Cyclones head into this game 5-1 for this season. In their last contest, the Cyclones played the Cincinnati Bearcats and took a loss by a score of 38-30. For the game, they ran 85 plays for 470 yds. The Iowa State Cyclones ended up running the ball 37 different times and accounted for 156 yards, which earned them an average of 4.2 yards per tote. Against the run, the Cyclones gave up 260 yds on 34 attempts, which averages out to 7.6 yds per rush surrendered. Iowa State allowed 13 completions on 25 attempts for 214 yards, and a completion rate of 52.0%.

The Cyclones have earned 2,396 yards in total over the course of this year. When it comes to getting the ball in the endzone, Iowa State has totaled 9 touchdowns through the air and 14 rushing touchdowns. They have surrendered the ball 5 times. Iowa State has accrued 129 1st downs as an offense, and they have been called for 21 infractions for 173 yards. As a team they're averaging 151.0 yards in the run game giving them a rank of 79th in the nation. Regarding scoring, the Iowa State Cyclones are averaging 31.3 points per game.

The Cyclones are ranked 31st in D-1 when it comes to team defense, conceding 18.2 PPG. The opposition is running for 4.6 yards per run and 141.8 rushing yards per game on the year. For the season, they have given up 851 yards on the ground through 6 games. In terms of yards through the air, the Cyclones have given up 1,171 yds which has them sitting in 72nd in college football. They have relinquished 195.2 yards per contest via the pass and allowed a completion percentage of 59.7%. In total, they are giving up 337.0 yards per contest which puts them 54th in D-1. They have allowed 7 touchdowns via the pass as well as 6 touchdowns running the ball.

Get all of our College Football Picks

The Buffaloes step onto the field holding a record of 2-4 for this season. In their last game, the Buffaloes took a loss by a score of 35-21 when they played the TCU Horned Frogs. Colorado relinquished 35 rush attempts for 94 yds (2.7 yards per rush). The Buffaloes passing defense gave up a completion percentage of 69.7%, surrendering 275 yards on 23 out of 33 passing. The Buffaloes finished with a total of 343 yds and they ran 65 plays (5.3 yds per play). Colorado ran the ball for 3.6 yds per attempt, finishing with a total of 126 yards on 35 attempts.

In relation to the points being put on the board, the Buffaloes are 89th in Division 1 scoring 25.0 points per game. The Colorado Buffaloes average 355.7 yards/game, which ranks them 92nd in the country. The Colorado offense has 293 yards of penalties on 32 infractions, which ranks them 74th in Division 1 in terms of making mistakes. They have given away 6 picks while allowing opponents to recover 2 fumbles and they have been able to earn 115 first downs. During the season to this point, the Buffaloes have thrown for a total of 1,271 yards through the air along with an average of 211.8 passing yards per game, ranking them 85th in the nation. They maintain an average of 143.8 yards per game on the ground and have rushed for 863 yards overall.

Colorado has allowed a total of 1,080 yards rushing (180.0 yards/game) and 8 touchdowns via the rush on the year. They have surrendered 9 touchdowns via the pass in addition to 218.8 yards per outing, which has them ranked 70th in the nation. This season, they have conceded 149 points. Their defense has compiled 3 fumbles and 2 picks this year. The Buffaloes defense has been on the field for 411 plays, ranking them 126th in D-1. The Buffaloes are giving up 24.8 PPG, which has them ranked 75th in Division 1.

Who will win tonight's Cyclones/Buffaloes college football game against the spread?

Josh's Pick: Take the Cyclones -4.0

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here