Iowa State Cyclones vs Oklahoma State Cowboys Prediction, 11/29/2025 College Football Picks, Best Bets & Odds

Game: Iowa State Cyclones vs Oklahoma State Cowboys

Date: Saturday, November 29, 2025

Location: Boone Pickens Stadium in Stillwater, OK

TV: ESPNU

Odds/Point Spread: Cowboys (+14.0)

Total/Over-Under: 48

The Oklahoma State Cowboys (1-10) will try to beat the Iowa State Cyclones (7-4) at Boone Pickens Stadium on Saturday, November 29, 2025. Oklahoma State is 14.0-point underdogs. The over/under comes in at 48.

The Iowa State Cyclones head into this game 7-4 for this year. In their last game, the Cyclones played against the Kansas Jayhawks and went home with a win by a final score of 38-14. The Iowa State Cyclones ended up running the ball 50 different times and totaled 221 yds, which had them averaging 4.4 yards per carry. In all, they ran 73 plays which gave them a total of 462 yds. Iowa State conceded 16 pass completions on 29 tries for a total of 191 yards, and a completion percentage of 55.2%. In the running game, the Cyclones conceded 132 yards on 21 tries, which is an average of 6.3 yds per run surrendered.

Regarding scoring, the Iowa State Cyclones have an average of 28.1 points per outing. As a team they're averaging 169.4 yards in the run game ranking them 58th in Division 1. The Cyclones have attained 4,407 total yards over the course of this season. When it comes to scoring, Iowa State has amassed 15 touchdowns via the pass and 22 rushing touchdowns. Iowa State has 237 1st downs as a unit, and they have been called for 50 infractions for 426 yds. They have turned the football over 13 times.

The Cyclones sit in 33rd in the country regarding team defense, allowing 20.8 points per game. Opposing teams are running for an average of 4.7 yards per rush on the ground and 148.1 rushing yards per game so far this season. In total, they have given up 1,629 rushing yards through 11 games. Regarding passing yards, the Cyclones are conceding 2,420 yds which ranks them 66th in the nation. They have conceded 220.0 yards per game via the pass and allowed a completion percentage of 60.7%. During this campaign, they are conceding 368.1 yards/game which has them ranked 65th in the nation. They have given up 14 touchdowns by air and 13 touchdowns via the ground game.

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The Cowboys come into this matchup with a record of 1-10 this season. When they last played, the Cowboys took a loss by a final score of 17-14 when they faced the UCF Knights. Oklahoma State allowed 36 running attempts for 125 yards (3.5 yds per carry). The Cowboys pass defense gave up a completion rate of 64.0%, relinquishing 271 yds on 16 for 25 through the air. The Cowboys finished the contest with 228 yards on 58 plays (3.9 yds per play). Oklahoma State rushed for 3.5 yards per tote, finishing the game with 104 yards on 30 carries.

Regarding putting points on the board, the Cowboys currently rank 134th in Division 1 by tallying 14.3 PPG. The Oklahoma State Cowboys hold an average of 298.2 yards/game, which ranks them 129th in college football. The Oklahoma State offense has totaled 534 yds of penalties on 61 infractions, which ranks 99th in college football in terms of making mistakes. They have thrown 9 picks while letting opponents recover 6 fumbles and they have recorded 176 first downs. Over the course of the season thus far, the Cowboys have earned 1,887 passing yards as well as holding an average of 171.5 passing yards per contest, which has them ranked 118th in Division 1. They maintain an average of 126.6 rushing yards per game and have run for 1,393 yards overall.

The Cowboys are surrendering 34.5 points per contest, which has them sitting 127th in the country. Oklahoma State has allowed a total of 1,758 rushing yards (159.8 yards/game) in addition to 17 touchdowns on the ground for the year. They have allowed 28 touchdowns via the pass and 265.1 yards/outing, which has them ranked 127th in Division 1. The Cowboys defense has taken part in 732 plays, ranking them 67th in college football. Their defense has totaled 6 fumbles and 6 picks for the year. Overall, they have given up 380 pts.

Who will win tonight's Cyclones/Cowboys college football game against the spread?

Josh's Pick: Take the Cyclones -14.0

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