Kansas Jayhawks vs Iowa State Cyclones Prediction, 11/22/2025 College Football Picks, Best Bets & Odds

Game: Kansas Jayhawks vs Iowa State Cyclones

Date: Saturday, November 22, 2025

Location: Jack Trice Stadium in Ames, IA

TV: FS1

Odds/Point Spread: Cyclones (-4.5)

Total/Over-Under: 55

The Iowa State Cyclones (6-4) host the Kansas Jayhawks (5-5) at Jack Trice Stadium on Saturday, November 22, 2025. Iowa State is 4.5-point favorites. The total is 55.

The Kansas Jayhawks step onto the field holding a record of 5-5 for this season. The last time they stepped onto the field, the Jayhawks played the Arizona Wildcats and ended up losing by a score of 24-20. In all, they tallied 70 plays which gave them a total of 369 yds. The Kansas Jayhawks ran the rock 40 times and tallied 170 yds, which is an average of 4.3 yds per attempt. Against the rush, the Jayhawks gave up 165 yards on 29 tries, which averages out to 5.7 yards per rush surrendered. Kansas surrendered 16 completions on 31 attempts for 158 yards, and a completion percentage of 51.6%.

The Jayhawks have tallied 3,886 total yards for the season. In terms of scoring touchdowns, Kansas has earned 21 touchdowns via the pass and 14 rushing touchdowns. They have given the ball to the opposition 9 different times. Kansas has 205 1st downs, and they have been hurt by 52 infractions for 420 yards. As a team they average 159.7 yards rushing which has them sitting 67th in college football. Concerning getting in the endzone, the Kansas Jayhawks hold an average of 30.2 points per outing.

Regarding passing yards, the Jayhawks are allowing 2,075 yds which ranks them 48th in college football. They have surrendered 207.5 yards per game through the air in addition to allowing a completion percentage of 63.2%. Overall, they are allowing 377.0 yards/game putting them 79th in the nation. They have given up 13 touchdowns via the pass as well as 17 touchdowns via the ground game. They are allowing teams to run for an average of 4.7 yards per running attempt and 169.5 rushing yards per game on the year. In total, they have allowed 1,695 rushing yards through 10 games. The Jayhawks rank 74th in Division 1 when it comes to the opposition scoring, allowing 25.2 points per game.

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The Cyclones come into this matchup with a record of 6-4 for this year. The last time they took the field, the Cyclones walked away with a victory by a final of 20-17 when they faced the TCU Horned Frogs. The Cyclones finished the contest with a total of 272 yards on 65 plays (4.2 yds per play). Iowa State ran the ball for 3.9 yards per attempt, finishing the game with 161 yards on 41 attempts. Iowa State conceded 30 run attempts for 113 yards (3.8 yds per rush). The Cyclones pass defense allowed a completion rate of 68.0%, surrendering 319 yds on 34 out of 50 through the air.

When it comes to the points being put on the board, the Cyclones are sitting 70th in Division 1 holding an average of 27.1 points per game. The Iowa State Cyclones hold an average of 394.5 yards per game, which has them ranked 64th in the nation. The Iowa State offense has accrued 396 yards of penalties on 47 violations, which ranks 116th in college football in terms of helping out the opposition. They have given away 9 picks while surrendering 4 fumbles and they have been able to tally 211 first downs. Over the course of the season thus far, the Cyclones have thrown for a total of 2,303 yards via the pass as well as an average of 230.3 passing yards per game, which is ranked 68th in Division 1. They hold an average of 164.2 yards per game via the ground game and have run for 1,642 yards for the season.

The Cyclones are giving up 21.5 points per contest, ranking them 40th in college football. Iowa State has conceded a total of 1,497 rushing yards (149.7 yards per game) as well as 12 touchdowns rushing so far this year. They have allowed the opposition 13 touchdowns via the pass as well as 222.9 yards per outing, which has them sitting 73rd in the nation. The Cyclones defense has participated in 653 plays, which is 47th in college football. They have totaled 6 fumbles recovered and 9 picks so far this year. In total, they have surrendered 215 total points.

Who will win tonight's Jayhawks/Cyclones college football game against the spread?

Tony's Pick: Take the Cyclones -4.5

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