Kansas Jayhawks vs Missouri Tigers Prediction, 9/6/2025 College Football Picks, Best Bets & Odds

Game: Kansas Jayhawks vs Missouri Tigers

Date: Saturday, September 6, 2025

Location: Memorial Stadium in Columbia, MO

TV: ESPN/ESPN+

Odds/Point Spread: Tigers (-6.5)

Total/Over-Under: 51

The Kansas Jayhawks (2-0) are hitting the road to Memorial Stadium on Saturday, September 6, 2025 where they will play the Missouri Tigers (1-0). Missouri opens this contest as 6.5-point favorites from oddsmakers. The betting total comes in at 51.

The Kansas Jayhawks step onto the field holding a record of 2-0 for this season. The last time they stepped onto the field, the Jayhawks played against the Wagner Seahawks and walked away with a win by a score of 46-7. In the running game, the Jayhawks gave up 53 yds on 28 attempts, which averages out to 1.9 yds per run surrendered. Kansas gave up 13 completions on 20 tries for a total of 90 yds, and a completion percentage of 65.0%. In the game, they ran 78 plays which totaled 631 yards. The Kansas Jayhawks ended up running the ball 44 times and totaled 285 yds, which came out to an average of 6.5 yards per tote.

Concerning putting the ball in the endzone, the Kansas Jayhawks have an average of 38.5 points per outing. As a team they average 246.0 yards rushing which ranks them 25th in the country. The Jayhawks have tallied 1,014 total yards for the year. In terms of getting the ball in the endzone, Kansas has compiled 7 touchdowns through the air and 3 touchdowns via the ground. Kansas has a total of 54 first downs as an offense, and they have committed 15 infractions for 127 yards. They have turned the football over 2 times.

When talking about passing yardage, the Jayhawks are allowing 269 yds which ranks them 108th in the country. They are allowing 134.5 yards per game via the pass in addition to giving up a completion percentage of 63.3%. For the year, they are allowing 179.5 yards/game which puts them 19th in the country. They have granted 1 touchdown via the pass in addition to 1 touchdown running the ball. Opposing teams are running for an average of 1.6 yards per rushing attempt and 45.0 yards on the ground per game on the season. For the season, they have allowed 90 yards via the ground game in 2 contests. The Jayhawks sit in 30th in Division 1 regarding the opposition scoring, conceding 7.0 points per game.

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The Tigers come into this matchup with a record of 1-0 for this season. When they last stepped on the field, the Tigers went home victorious with a score of 61-6 against the Central Arkansas Bears. Missouri rushed the football for 5.8 yards per attempt, finishing with 219 yds on 38 attempts. The Tigers ended up finishing with 560 yds while they ran 69 plays (8.1 yds per play). The Tigers pass defense gave up a completion rate of 56.5%, surrendering 73 yds on 13 for 23 through the air. Missouri relinquished 39 rush attempts for 154 yards (3.9 yds per carry).

The Missouri Tigers average 560.0 yards per game, ranking them 9th in the nation. The Missouri offense has 70 penalty yards on 8 infractions, which is 22nd in D-1 in terms of giving up free yards. They are averaging 219.0 yards per game. They have been able to obtain 25 first downs. When discussing the points being put on the board, the Tigers currently rank 6th in the nation by scoring 61.0 points per outing. During this campaign so far, the Tigers currently sit at 341 yards via the pass, ranking them 13th in the country.

Missouri has yielded a total of 154 yards on the ground. They have given up 1 touchdown through the air and 73.0 yards/contest, which has them sitting 11th in Division 1. Their defense has totaled 1 fumble and 1 interception so far this season. The Tigers defense has taken the field for 62 plays, which has them ranked 52nd in D-1. The Tigers are allowing 6.0 PPG, ranking them 17th in the country.

Who will win tonight's Jayhawks/Tigers college football game against the spread?

Guy's Pick: Take the Jayhawks +6.5

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