Kentucky Wildcats vs Louisville Cardinals Prediction, 11/29/2025 College Football Picks, Best Bets & Odds

Game: Kentucky Wildcats vs Louisville Cardinals

Date: Saturday, November 29, 2025

Location: L&N Federal Credit Union Stadium in Louisville, KY

TV: ACC Network

Odds/Point Spread: Cardinals (-3.0)

Total/Over-Under: 47

The Louisville Cardinals (7-4) will try to defeat the Kentucky Wildcats (5-6) at L&N Federal Credit Union Stadium on Saturday, November 29, 2025. Kentucky opens this contest as 3.0-point dogs from Vegas oddsmakers. The over/under is 47.

The Kentucky Wildcats head into this matchup 5-6 this season. In their last contest, the Wildcats faced the Vanderbilt Commodores and went home with a loss by a final score of 45-17. The Kentucky Wildcats rushed the ball a total of 19 different times and accrued 31 yds, which came out to an average of 1.6 yds per attempt. Overall, they ran 68 plays which gave them a total of 315 yds. Kentucky allowed 37 completions on 44 tries for 539 yards, and a completion percentage of 84.1%. When it came to stopping the run, the Wildcats conceded 65 yards on 25 tries, which calculates to 2.6 yards per run allowed.

When talking about scoring points, the Kentucky Wildcats are sitting at 25.1 PPG. Offensively they hold an average of 148.2 yards in the run game giving them a rank of 77th in college football. The Wildcats have earned 3,953 yards in total for the season. When it comes to distribution of touchdowns, Kentucky has amassed 15 touchdowns via the pass and 19 rushing touchdowns. Kentucky has compiled 227 first downs as an offense, and they have committed 54 penalties for 438 yards. They have surrendered the football 20 times.

In terms of yards through the air, the Wildcats have given up 2,697 yards which ranks them 107th in the nation. They have surrendered 245.2 yards per outing through the air in addition to allowing a completion percentage of 62.1%. In total, they have surrendered 368.2 yards/outing which ranks them 66th in college football. They have allowed 13 touchdowns through the air and 18 touchdowns on the ground. They are giving up an average of 3.5 yards per running attempt and 123.0 rushing yards per contest on the campaign. Overall, they have conceded 1,353 yards via the ground game in 11 games. The Wildcats rank 71st in D-1 when it comes to team defense, giving up 25.1 points per contest.

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The Cardinals step onto the field holding a record of 7-4 this year. When they last stepped on the gridiron, the Cardinals took a loss by a score of 38-6 when they played the SMU Mustangs. Louisville ran for 4.4 yards per tote, totaling 128 yds on 29 attempts. The Cardinals finished the game with 228 yds while running 49 plays (4.7 yds per play). The Cardinals pass defense gave up a completion percentage of 78.9%, surrendering 307 yds on 30 out of 38 through the air. Louisville relinquished 36 run attempts for 178 yds (4.9 yards per rush).

The Louisville Cardinals have an average of 384.2 yards per outing, which ranks them 70th in D-1. The Louisville offense has racked up 699 yds of penalties on 75 infractions, which is 41st in college football in terms of giving up free yards. They are averaging 153.9 yards per game via the rush and have run for 1,693 yards overall. They have thrown 9 interceptions while conceding 7 fumbles and they have earned 209 first downs. Regarding their ability to score points, the Cardinals currently sit 55th in Division 1 by scoring 29.2 PPG. For the year thus far, the Cardinals have thrown for 2,533 passing yards as well as an average of 230.3 passing yards per game, which ranks 67th in the country.

The Cardinals are relinquishing 23.0 points per game, which puts them 54th in the country. Louisville has yielded a total of 1,277 yards on the ground (116.1 yards per game) in addition to 12 touchdowns via the rush on the year. They have allowed the opposition 14 touchdowns from the passing game and 198.8 yards/game, which has them sitting 39th in D-1. The Cardinals defense has been on the field for 716 plays, which has them ranked 45th in Division 1. They have earned 6 fumbles and 12 picks on the season. Overall, they have surrendered 253 points.

Who will win tonight's Wildcats/Cardinals college football game against the spread?

Tony's Pick: Take the Wildcats +3.0

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