Kentucky Wildcats vs South Carolina Gamecocks Prediction, 9/27/2025 College Football Picks, Best Bets & Odds

Game: Kentucky Wildcats vs South Carolina Gamecocks

Date: Saturday, September 27, 2025

Location: Williams-Brice Stadium in Columbia, SC

TV: SEC Network

Odds/Point Spread: Gamecocks (-6.5)

Total/Over-Under: 47

Williams-Brice Stadium is the site where the South Carolina Gamecocks (2-2) will play the Kentucky Wildcats (2-1) on Saturday, September 27, 2025. Kentucky is 6.5-point underdogs from oddsmakers. The total has been set at 47.

The Kentucky Wildcats come into this game with a record of 2-1 for this year. In their last contest, the Wildcats took the field against the Eastern Michigan Eagles and earned the victory with a final of 48-23. Overall, they ran 67 plays which converted into 492 yards. The Kentucky Wildcats ran the ball 46 different times and totaled 252 yards, which came out to an average of 5.5 yards per attempt. When it came to the battle of the line of scrimmage, the Wildcats gave up 131 yds on 30 tries, which is an average of 4.4 yds per rush surrendered. Kentucky conceded 25 completions on 43 attempts for 330 yds, and a completion percentage of 58.1%.

The Wildcats have racked up 1,156 total yards for the season. When it comes to getting the ball in the endzone, Kentucky has compiled 2 passing touchdowns and 9 touchdowns on the ground. They have turned the football over 2 different times. Kentucky has a total of 60 first downs as a team, and they have been called for 16 penalties for 148 yds. As a team they hold an average of 214.7 yards on the ground ranking them 28th in D-1. When talking about putting points on the board, the Kentucky Wildcats are averaging 31.7 points per outing.

Regarding yards via the pass, the Wildcats have allowed 835 yards which puts them in 81st in Division 1. They have given up 278.3 yards per contest via the pass in addition to allowing a completion percentage of 56.9%. In total, they are conceding 415.0 yards per outing which ranks them 116th in the nation. They have allowed 2 touchdowns through the air in addition to 5 touchdowns pounding the rock. Opposing teams are running for an average of 3.8 yards per rush and 136.7 yards on the ground per contest for the campaign. During the season, they have conceded 410 running yards through 3 games. The Wildcats are sitting in 72nd in the country when it comes to team defense, giving up 23.0 points per game.

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The Gamecocks head into this game 2-2 this season. When they last stepped on the field, the Gamecocks went home defeated by a final of 29-20 against the Missouri Tigers. The Gamecocks finished the contest with a total of 293 yds while running 50 plays (5.9 yds per play). South Carolina ran for -0.4 yards per tote, finishing with a total of -9 yards on 22 attempts. South Carolina relinquished 48 rushing attempts for 285 yds (5.9 yards per rush). The Gamecocks secondary gave up a completion percentage of 59.3%, surrendering 171 yards on 16 for 27 passing.

Regarding their ability to score points, the Gamecocks rank 99th in college football averaging 22.3 PPG. The South Carolina Gamecocks hold an average of 300.5 yards per game, which has them sitting 123rd in the nation. The South Carolina offense has compiled 282 yards of penalties on 37 violations, which is 6th in D-1 in terms of hurting your team. They have tossed 2 interceptions while conceding 2 fumbles and they have been able to obtain 67 1st downs. Over the course of the season thus far, the Gamecocks have thrown for 881 passing yards as well as an average of 220.3 passing yards per outing, which has them ranked 77th in the nation. They hold an average of 80.3 yards per game via the rush and have run for 321 yards for the year.

South Carolina has allowed a total of 608 rushing yards (152.0 yards per contest) and 4 touchdowns via the rush for the campaign. They have allowed 4 touchdowns via the pass as well as 194.3 yards/game, which puts them in 58th in Division 1. In total, they have conceded 81 points. They have tallied 1 fumble recovered and 4 interceptions on the year. The Gamecocks defense has taken part in 272 plays, which is 93rd in college football. The Gamecocks are giving up 20.3 points per game, ranking them 54th in D-1.

Who will win tonight's Wildcats/Gamecocks college football game against the spread?

Guy's Pick: Take the Gamecocks -6.5

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