Kentucky Wildcats vs Vanderbilt Commodores Prediction, 11/22/2025 College Football Picks, Best Bets & Odds

Game: Kentucky Wildcats vs Vanderbilt Commodores

Date: Saturday, November 22, 2025

Location: FirstBank Stadium in Nashville, TN

TV: ESPN

Odds/Point Spread: Commodores (-10.0)

Total/Over-Under: 54

The Kentucky Wildcats (5-5) are traveling to FirstBank Stadium on Saturday, November 22, 2025 where they will try to defeat the Vanderbilt Commodores (8-2). Vanderbilt opens as 10.0-point favorites from Vegas oddsmakers. The over/under has been set at 54.

The Kentucky Wildcats step onto the field holding a record of 5-5 for this season. In their last contest, the Wildcats played the Tennessee Tech Golden Eagles and went home with a win by a final score of 42-10. The Kentucky Wildcats ran the football 39 different times and accrued 207 yards, which came out to an average of 5.3 yds per attempt. In all, they had 66 plays which gave them 468 yds. Kentucky surrendered 20 completions on 37 attempts for 143 yds, and a completion rate of 54.1%. Against the rush, the Wildcats conceded 104 yds on 32 tries, which is an average of 3.3 yards per run surrendered.

The Wildcats have earned 3,638 total yards for this campaign. With reference to getting the ball in the endzone, Kentucky has amassed 13 touchdowns through the air and 19 touchdowns via the ground. They have surrendered the ball 17 different times. Kentucky has earned 209 first downs as an offense, and they have been flagged for 47 infractions for 373 yards. As a team they maintain an average of 159.9 yards via the ground game which has them sitting 66th in the country. Concerning scoring, the Kentucky Wildcats have an average of 25.9 points per game.

The Wildcats sit in 55th in Division 1 when it comes to team defense, giving up 23.1 PPG. They are giving up 3.5 yards per rush and 128.8 rushing yards per game for the season. Over the course of this season, they have allowed 1,288 rushing yards through 10 games. Regarding yards through the air, the Wildcats have allowed 2,158 yards which ranks them 57th in college football. They are conceding 215.8 yards per game via the pass as well as conceding a completion percentage of 58.7%. For the year, they are allowing 344.6 yards/contest which has them ranked 50th in the nation. They have yielded 8 touchdowns via the pass and 17 touchdowns on the ground.

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The Commodores come into this game with a record of 8-2 this season. In their last game, the Commodores went home victorious with a score of 45-38 when they played the Auburn Tigers. Vanderbilt conceded 36 run attempts for 210 yds (5.8 yards per rush). The Commodores secondary gave up a completion percentage of 67.4%, relinquishing 353 yds on 31 out of 46 through the air. The Commodores finished with a total of 544 yards while running 69 plays (7.9 yds per play). Vanderbilt ran for 4.6 yds per carry, finishing the contest with 167 yards on 36 attempts.

The Vanderbilt Commodores have an average of 443.6 yards/contest, which ranks them 24th in D-1. The Vanderbilt offense has totaled 617 yds of penalties on 67 violations, which ranks them 47th in the nation in terms of helping out the other team. They are averaging 185.2 yards per game on the ground and have rushed for 1,852 yards for the season. They have thrown 5 picks while losing 4 fumbles and they have been able to obtain 235 first downs. In terms of how much they score, the Commodores are ranked 9th in D-1 holding an average of 38.3 points per contest. During the season so far, the Commodores have thrown for a total of 2,584 yards via the pass as well as holding an average of 258.4 throwing yards per game, ranking them 40th in college football.

Vanderbilt has conceded a total of 1,125 yards on the ground (112.5 yards/game) and 6 touchdowns via the rush this season. They have given up 19 touchdowns from the passing game and 244.7 yards/contest, which has them sitting 106th in the nation. This season, they have surrendered 222 total points. They have compiled 7 fumbles recovered and 4 picks this year. The Commodores defense has taken part in 638 plays, which is good for 32nd in the nation. The Commodores are conceding 22.2 points per game, which has them 48th in the country.

Who will win tonight's Wildcats/Commodores college football game against the spread?

Josh's Pick: Take the Commodores -10.0

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