Louisville Cardinals vs Miami Hurricanes Prediction, 10/17/2025 College Football Picks, Best Bets & Odds

Game: Louisville Cardinals vs Miami Hurricanes

Date: Friday, October 17, 2025

Location: Hard Rock Stadium in Miami Gardens, FL

TV: ESPN

Odds/Point Spread: Hurricanes (-13.5)

Total/Over-Under: 53

The Louisville Cardinals (4-1) are en route to Hard Rock Stadium on Friday, October 17, 2025 where they will try to beat the Miami Hurricanes (5-0). Louisville opens as 13.5-point underdogs from Vegas oddsmakers. The over/under is set at 53.

The Louisville Cardinals step onto the field holding a record of 4-1 this year. In their last matchup, the Cardinals played the Virginia Cavaliers and walked away from this one with a loss by a score of 30-27. When it came to the battle of the line of scrimmage, the Cardinals gave up 88 yards on 32 attempts, which is 2.8 yds per run allowed. Louisville surrendered 19 completions on 31 tries for 149 yds, and a completion rate of 61.3%. In all, they had 75 plays which totaled 383 yards. The Louisville Cardinals ran the football 27 different times and accrued 54 yds, earning them an average of 2.0 yards per attempt.

In terms of putting points on the board, the Louisville Cardinals are averaging 36.0 points per game. Offensively they're holding an average of 115.0 yards via the ground game which is 113th in Division 1. The Cardinals have racked up 2,020 total yards this season. When it comes to distribution of touchdowns, Louisville has earned 8 touchdowns through the air and 10 rushing touchdowns. Louisville has a total of 110 1st downs, and they have been flagged for 37 infractions for 362 yds. They have given the ball to the opposition 8 different times.

The Cardinals are sitting in 48th in the country regarding team defense, conceding 21.0 PPG. The opposition is running for an average of 3.3 yards per rushing attempt and 111.6 rushing yards per contest on the campaign. For the year, they have given up 558 rushing yards through 5 games. When it comes to passing yardage, the Cardinals have allowed 752 yards which has them sitting in 2nd in Division 1. They have yielded 150.4 yards per contest via the pass and giving up a completion percentage of 54.3%. Over the course of this season, they have surrendered 262.0 yards per outing which puts them 12th in the nation. They have allowed 5 touchdowns via the pass as well as 4 touchdowns running the ball.

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The Hurricanes step onto the field holding a record of 5-0 for this year. For their last game, the Hurricanes got the victory with a final of 28-22 against the Florida State Seminoles. The Hurricanes finished the game with 338 yds and they ran 59 plays (5.7 yds per play). Miami ran for 3.0 yards per tote, finishing the game with 97 yds on 32 carries. Miami allowed 38 running attempts for 132 yds (3.5 yards per carry). The Hurricanes pass defense conceded a completion rate of 55.6%, relinquishing 272 yards on 25 out of 45 through the air.

When it comes to their ability to score points, the Hurricanes rank 35th in D-1 with 35.0 PPG. The Miami Hurricanes hold an average of 428.0 yards per contest, ranking them 41st in the nation. The Miami offense has racked up 314 yards of penalties on 38 infractions, which ranks them 59th in the country in terms of giving up free yards. They have given away 3 picks while conceding 0 fumbles and they have obtained 113 first downs. During the season to this point, the Hurricanes have thrown for 1,321 yards via the pass together with holding an average of 264.2 throwing yards per contest, putting them at 39th in the country. They are averaging 163.8 yards per game on the ground and have run for 819 yards in total.

The Hurricanes are relinquishing 13.6 points per game, which has them ranked 9th in the country. Miami has conceded a total of 437 yards on the ground (87.4 yards per contest) as well as 2 touchdowns via the rush so far this year. They have allowed 5 touchdowns from the passing game and 189.0 yards per outing, which puts them in 35th in the nation. The Hurricanes defense has been on the field for 312 plays, which has them ranked 2nd in the nation. They have totaled 4 fumbles and 5 picks for the year. Over the course of the season, they have surrendered 68 total points.

Who will win tonight's Cardinals/Hurricanes college football game against the spread?

Josh's Pick: Take the Hurricanes -13.5

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