Louisville Cardinals vs Virginia Tech Hokies Prediction, 11/1/2025 College Football Picks, Best Bets & Odds

Game: Louisville Cardinals vs Virginia Tech Hokies

Date: Saturday, November 1, 2025

Location: Lane Stadium in Blacksburg, VA

TV: The CW Network

Odds/Point Spread: Hokies (+10.0)

Total/Over-Under: 54

The Virginia Tech Hokies (3-5) will try to beat the Louisville Cardinals (5-1) at Lane Stadium on Saturday, November 1, 2025. Virginia Tech is 10.0-point dogs from Vegas oddsmakers. The over/under is set at 54.

The Louisville Cardinals head into this matchup 5-1 for this year. In their last game, the Cardinals played the Boston College Eagles and walked away with a win by a score of 38-24. On the day, they tallied 59 plays which totaled 504 yards. The Louisville Cardinals ended up running the ball 31 times and accounted for 317 yards, which came out to an average of 10.2 yards per attempt. On the ground, the Cardinals gave up 116 yds on 36 attempts, which calculates to 3.2 yards per rush surrendered. Louisville relinquished 23 pass completions on 46 attempts for a total of 244 yards, and a completion percentage of 50.0%.

The Cardinals have tallied 2,891 total yards for the year. In terms of scoring touchdowns, Louisville has earned 11 touchdowns via the pass and 15 rushing touchdowns. They have surrendered the ball 12 different times. Louisville has accounted for 147 first downs as a team, and they have been called for 49 infractions for 471 yards. As a unit they're maintaining an average of 144.4 yards rushing which ranks them 79th in Division 1. When talking about getting in the endzone, the Louisville Cardinals have an average of 34.6 points per game.

When talking about yards via the pass, the Cardinals have given up 1,267 yds which has them ranked 17th in the country. They have allowed 181.0 yards per outing through the air and conceding a completion percentage of 56.3%. In total, they are giving up 286.3 yards per outing which has them ranked 14th in D-1. They have yielded 8 touchdowns by air as well as 6 touchdowns via the ground game. They are allowing teams to run for an average of 3.2 yards per rushing attempt and 105.3 rushing yards per game for the campaign. For the year, they have conceded 737 yards via the running game in 7 outings. The Cardinals are ranked 44th in the nation when it comes to team defense, conceding 21.4 points per game.

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The Hokies come into this game with a record of 3-5 this year. The last time they took the field, the Hokies walked away with a victory by a final of 42-34 against the California Golden Bears. Virginia Tech allowed 27 rush attempts for 39 yards (1.4 yards per carry). The Hokies passing defense conceded a completion rate of 60.0%, surrendering 286 yds on 24 for 40 through the air. The Hokies finished the contest with a total of 476 yards while they ran 76 plays (6.3 yards per play). Virginia Tech ran the ball for 6.2 yds per attempt, finishing with 357 yds on 58 attempts.

The Virginia Tech Hokies maintain an average of 373.8 yards per contest, which has them sitting 80th in D-1. The Virginia Tech offense has compiled 547 penalty yards on 60 infractions, which is 15th in D-1 in terms of giving up free yards. They have an average of 184.3 yards per game on the ground and have rushed for 1,474 yards overall. They have tossed 6 interceptions while conceding 3 fumbles and they have been able to tally 165 1st downs. When discussing their ability to score points, the Hokies are ranked 85th in college football holding an average of 25.4 points per game. During this campaign so far, the Hokies have racked up 1,516 yards via the pass in addition to holding an average of 189.5 passing yards per contest, giving them a rank of 105th in Division 1.

The Hokies are surrendering 29.9 points per game, which has them ranked 106th in the nation. Virginia Tech has surrendered a total of 1,087 yards on the ground (135.9 yards/game) and 17 touchdowns on the ground this year. They have surrendered 11 touchdowns through the air in addition to 231.3 yards/outing, which puts them in 89th in Division 1. The Hokies defense has been on the field for 496 plays, which has them sitting 55th in the nation. They have earned 2 fumbles and 3 picks so far this season. This year, they have allowed 239 total points.

Who will win tonight's Cardinals/Hokies college football game against the spread?

Tony's Pick: Take the Hokies +10.0

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