LSU Tigers vs Vanderbilt Commodores Prediction, 10/18/2025 College Football Picks, Best Bets & Odds

Game: LSU Tigers vs Vanderbilt Commodores

Date: Saturday, October 18, 2025

Location: FirstBank Stadium in Nashville, TN

TV: ABC

Odds/Point Spread: Commodores (-2.5)

Total/Over-Under: 49

The LSU Tigers (5-1) are on their way to FirstBank Stadium on Saturday, October 18, 2025 where they will take on the Vanderbilt Commodores (5-1). Vanderbilt opens as 2.5-point favorites from Vegas oddsmakers. The over/under comes in at 49.

The LSU Tigers head into this matchup 5-1 for this season. In their last matchup, the Tigers stepped onto the field against the South Carolina Gamecocks and walked away with a win by a score of 20-10. On the ground, the Tigers gave up 193 yards on 45 attempts, which averages out to 4.3 yds per rush allowed. LSU conceded 15 completions on 27 tries for 124 yards, and a completion rate of 55.6%. For the game, they ran 63 plays which gave them 420 yds. The LSU Tigers ended up rushing 30 different times and had 166 yds, which is an average of 5.5 yds per carry.

The Tigers have earned 2,241 yards in total for the season. When it comes to getting the ball in the endzone, LSU has totaled 10 touchdowns via the pass and 7 touchdowns via the ground. They have turned the ball over 8 times. LSU has 132 first downs as an offense, and they have been hurt by 41 penalties for 372 yards. Offensively they're averaging 115.0 yards via the ground game which ranks them 114th in the nation. In terms of getting in the endzone, the LSU Tigers hold an average of 25.8 points per contest.

The Tigers are ranked 5th in the nation regarding team defense, giving up 11.8 points per contest. They are giving up 3.2 yards per tote and 102.5 yards on the ground per game for the season. In total, they have given up 615 yards via the running game in 6 games. In terms of passing yardage, the Tigers have conceded 1,167 yds which puts them in 40th in the nation. They have conceded 194.5 yards per contest via the pass in addition to allowing a completion percentage of 58.0%. Overall, they have relinquished 297.0 yards/outing which ranks them 21st in Division 1. They have yielded 4 touchdowns by air as well as 4 touchdowns on the ground.

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The Commodores come into this matchup with a record of 5-1 this season. When they last stepped on the field, the Commodores took a loss by a score of 30-14 against the Alabama Crimson Tide. Vanderbilt ended up running for 7.1 yds per attempt, finishing the contest with 135 yards on 19 carries. The Commodores finished with 333 yards on 55 plays (6.1 yards per play). The Commodores secondary allowed a completion rate of 74.2%, surrendering 340 yards on 23 out of 31 passing. Vanderbilt conceded 38 rushing attempts for 146 yards (3.8 yds per rush).

The Vanderbilt Commodores are averaging 467.5 yards per game, which has them sitting 19th in Division 1. The Vanderbilt offense has accrued 408 yards of penalties on 44 violations, which ranks 28th in the country in terms of helping out the other team. They average 208.7 yards per game via the rush and have run for 1,252 yards for this year. They have thrown 4 interceptions while allowing opponents to recover 2 fumbles and they have earned 147 1st downs. In relation to how much they score, the Commodores are sitting 7th in college football holding an average of 43.2 points per game. During this campaign so far, the Commodores have compiled 1,553 passing yards as well as holding an average of 258.8 passing yards per game, ranking them 47th in the nation.

Vanderbilt has surrendered a total of 545 yards on the ground (90.8 yards/game) and 3 touchdowns on the ground so far this season. They have surrendered 11 touchdowns through the air and 222.5 yards/game, ranking them 69th in college football. This season, they have conceded 116 points in total. Their defense has totaled 6 fumbles and 4 picks so far this season. The Commodores defense has participated in 369 plays, which is 29th in Division 1. The Commodores are surrendering 19.3 PPG, which has them 36th in the country.

Who will win tonight's Tigers/Commodores college football game against the spread?

Guy's Pick: Take the Tigers +2.5

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