Missouri Tigers vs Oklahoma Sooners Prediction, 11/22/2025 College Football Picks, Best Bets & Odds

Game: Missouri Tigers vs Oklahoma Sooners

Date: Saturday, November 22, 2025

Location: Memorial Stadium in Norman, OK

TV: ABC

Odds/Point Spread: Sooners (-7.5)

Total/Over-Under: 42.5

Memorial Stadium is the site where the Oklahoma Sooners (8-2) will take on the Missouri Tigers (7-3) on Saturday, November 22, 2025. Oklahoma is 7.5-point favorites from Vegas oddsmakers. The total is 42.5.

The Missouri Tigers come into this game with a record of 7-3 for this season. In their last matchup, the Tigers took the field against the Mississippi State Bulldogs and earned the victory with a final of 49-27. In the running game, the Tigers conceded 243 yds on 39 attempts, which averages out to 6.2 yards per rush surrendered. Missouri conceded 20 completions on 29 tries for a total of 221 yds, and a completion percentage of 69.0%. Once the final whistle blew, they had 55 plays which gave them a total of 438 yds. The Missouri Tigers ran the ball 39 times and accounted for 326 yds, earning them an average of 8.4 yards per attempt.

When it comes to scoring, the Missouri Tigers are averaging 34.9 points per contest. As a unit they're maintaining an average of 241.7 yards in the run game which ranks them 6th in Division 1. The Tigers have earned 4,504 total yards for the year. When it comes to scoring touchdowns, Missouri has amassed 15 touchdowns via the pass and 27 touchdowns on the ground. Missouri has accumulated 241 1st downs, and they have been called for 55 penalties for 529 yds. They have given the ball to the opposition 13 different times.

The Tigers rank 26th in college football in terms of team defense, allowing 19.9 PPG. They are giving up an average of 3.4 yards per rush on the ground and 107.6 yards on the ground per contest on the season. In total, they have allowed 1,076 rushing yards through 10 games. Concerning yards through the air, the Tigers are giving up 1,699 yds which has them ranked 14th in the nation. They have relinquished 169.9 yards per contest via the pass and allowed a completion percentage of 56.6%. In total, they are giving up 277.5 yards/outing putting them 10th in the nation. They have surrendered 12 touchdowns via the pass and 11 touchdowns via the ground game.

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The Sooners come into this matchup with a record of 8-2 this season. In their last game, the Sooners got the victory with a final of 23-21 when they played the Alabama Crimson Tide. Oklahoma rushed for 2.6 yards per carry, finishing with a total of 74 yds on 28 carries. The Sooners finished with a total of 212 yards on 51 plays (4.2 yds per play). The Sooners pass defense allowed a completion rate of 64.4%, relinquishing 393 yards on 29 for 45 passing. Oklahoma surrendered 35 attempts on the ground for 63 yds (1.8 yds per rush).

The Oklahoma Sooners have an average of 357.5 yards per game, which has them sitting 89th in college football. The Oklahoma offense has totaled 605 yards of penalties on 68 infractions, which ranks them 43rd in Division 1 in terms of helping out the other team. They maintain an average of 130.7 rushing yards per game and have toted the ball for 1,307 yards in total. They have given away 7 picks while losing 5 fumbles and they have been able to obtain 194 first downs. Regarding their ability to score points, the Sooners sit 63rd in the nation holding an average of 28.3 points per game. For the year to this point, the Sooners have thrown for a total of 2,268 passing yards as well as an average of 226.8 passing yards per contest, which has them sitting 71st in the country.

The Sooners are surrendering 14.8 points per game, which has them ranked 8th in the country. Oklahoma has allowed a total of 822 yards via the ground game (82.2 yards per outing) in addition to 6 touchdowns via the rush on the season. They have given up 8 touchdowns through the air in addition to 196.2 yards/contest, which has them ranked 37th in the country. The Sooners defense has been on the field for 647 plays, which has them sitting 40th in the nation. They have 4 fumbles and 6 interceptions over the course of the season. This year, they have surrendered 148 total points.

Who will win tonight's Tigers/Sooners college football game against the spread?

Tony's Pick: Take the Tigers +7.5

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