NC State Wolfpack vs Pittsburgh Panthers Prediction, 10/25/2025 College Football Picks, Best Bets & Odds

Game: NC State Wolfpack vs Pittsburgh Panthers

Date: Saturday, October 25, 2025

Location: Acrisure Stadium in Pittsburgh, PA

TV: ACC Network

Odds/Point Spread: Panthers (-6.5)

Total/Over-Under: 57

The NC State Wolfpack (4-3) are on their way to Acrisure Stadium on Saturday, October 25, 2025 where they will compete against the Pittsburgh Panthers (5-2). NC State is 6.5-point dogs. The betting total is set at 57.

The NC State Wolfpack come into this matchup with a record of 4-3 for this season. The last time they took the field, the Wolfpack took on the Notre Dame Fighting Irish and went home with a loss by a final score of 36-7. The NC State Wolfpack ended up rushing 28 times and amassed 51 yards, which had them averaging 1.8 yards per tote. In all, they ran 59 plays for 233 yards. NC State allowed 19 pass completions on 32 attempts for a total of 342 yds, and a completion rate of 59.4%. On the ground, the Wolfpack conceded 143 yards on 39 attempts, which is an average of 3.7 yards per rush surrendered.

In terms of putting points on the board, the NC State Wolfpack have an average of 30.0 points per game. As a team they hold an average of 149.0 yards on the ground which has them sitting 75th in D-1. The Wolfpack have earned 2,919 total yards this season. In terms of notching touchdowns, NC State has compiled 14 touchdowns via the pass and 14 rushing touchdowns. NC State has tallied 151 first downs offensively, and they have been called for 38 penalties for 362 yards. They have surrendered the football 10 different times.

The Wolfpack sit in 88th in D-1 in terms of the opposition scoring, conceding 26.6 points per contest. Opposing teams are running for an average of 4.2 yards per rushing attempt and 133.4 yards on the ground per game on the campaign. Over the course of this year, they have conceded 934 yards on the ground through 7 games. When talking about yards through the air, the Wolfpack are allowing 1,801 yds which has them ranked 121st in the nation. They have given up 257.3 yards per contest through the air and conceding a completion percentage of 64.3%. Over the course of this year, they have surrendered 390.7 yards/contest which ranks them 95th in D-1. They have given up 10 touchdowns via the pass as well as 11 touchdowns on the ground.

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The Panthers come into this matchup with a record of 5-2 for this year. In their last game, the Panthers got the victory with a final of 30-13 against the Syracuse Orange. Pittsburgh surrendered 30 running attempts for 76 yds (2.5 yards per rush). The Panthers pass defense gave up a completion rate of 50.0%, relinquishing 136 yds on 17 out of 34 passing. The Panthers finished the game with 255 yds on 67 plays (3.8 yds per play). Pittsburgh ran the ball for 2.7 yds per attempt, finishing the contest with 115 yards on 43 attempts.

The Pittsburgh Panthers have an average of 406.6 yards per outing, which ranks them 57th in the country. The Pittsburgh offense has totaled 488 yards of penalties on 55 infractions, which is good for 12th in college football in terms of giving up free yards. They average 121.4 yards per game via the ground game and have toted the ball for 850 yards overall. They have given away 9 interceptions while losing 2 fumbles and they have obtained 142 1st downs. When it comes to the points being put on the board, the Panthers are sitting 13th in the nation averaging 38.4 points per contest. For the year to this point, the Panthers have thrown for a total of 1,996 yards through the air along with an average of 285.1 passing yards per game, putting them at 20th in the nation.

Pittsburgh has allowed a total of 577 yards rushing (82.4 yards per game) and 6 touchdowns by way of the ground game on the season. They have surrendered 12 touchdowns through the air and 216.7 yards/game, which puts them in 60th in D-1. This year, they have allowed 142 total points. Their defense has compiled 4 fumbles and 7 interceptions this season. The Panthers defense has participated in 482 plays, which is good for 98th in D-1. The Panthers are surrendering 20.3 PPG, which has them 39th in college football.

Who will win tonight's Wolfpack/Panthers college football game against the spread?

Josh's Pick: Take the Panthers -6.5

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