Nevada Wolf Pack vs Wyoming Cowboys Prediction, 11/22/2025 College Football Picks, Best Bets & Odds

Game: Nevada Wolf Pack vs Wyoming Cowboys

Date: Saturday, November 22, 2025

Location: War Memorial Stadium in Laramie, WY

TV: ESPN+

Odds/Point Spread: Cowboys (-6.5)

Total/Over-Under: 41

War Memorial Stadium is the location where the Wyoming Cowboys (4-6) will try to beat the Nevada Wolf Pack (2-8) on Saturday, November 22, 2025. Nevada is 6.5-point dogs. The total comes in at 41.

The Nevada Wolf Pack come into this game with a record of 2-8 for this year. The last time they stepped onto the field, the Wolf Pack played the San Jose State Spartans and walked away with a win by a score of 55-10. Against the run, the Wolf Pack gave up 145 yards on 40 attempts, which is 3.6 yards per run allowed. Nevada gave up 24 pass completions on 35 tries for a total of 377 yds, and a completion percentage of 68.6%. Once the final whistle blew, they tallied 61 plays which totaled 413 yards. The Nevada Wolf Pack ended up rushing 42 different times and tallied 218 yds, earning them an average of 5.2 yds per attempt.

The Wolf Pack have tallied 3,014 total yards for the year. With reference to scoring touchdowns, Nevada has compiled 9 passing touchdowns and 7 touchdowns on the ground. They have turned the ball over 24 times. Nevada has 167 1st downs as an offense, and they have committed 50 penalties for 435 yards. As a team they average 143.6 yards rushing which ranks them 84th in the country. When talking about scoring points, the Nevada Wolf Pack have an average of 18.1 points per outing.

In terms of yards through the air, the Wolf Pack have given up 2,221 yards which has them sitting in 69th in college football. They have yielded 222.1 yards per game via the pass as well as conceding a completion percentage of 65.9%. For the year, they have surrendered 372.2 yards per game ranking them 72nd in the country. They have given up 10 touchdowns through the air and 19 touchdowns on the ground. The opposition is running for 4.0 yards per tote and 150.1 rushing yards per contest for the campaign. Over the course of this year, they have allowed 1,501 yards on the ground through 10 games. The Wolf Pack are ranked 93rd in Division 1 regarding their opponents scoring, allowing 28.1 points per game.

Get all of our College Football Picks Against the Spread

The Cowboys come into this matchup with a record of 4-6 for this year. When they last stepped on the gridiron, the Cowboys took a loss by a score of 24-3 when they played the Fresno State Bulldogs. Wyoming ran the ball for 3.3 yards per tote, totaling 107 yards on 32 attempts. The Cowboys finished with 184 yards while running 60 plays (3.1 yds per play). The Cowboys pass defense conceded a completion percentage of 50.0%, surrendering 194 yards on 11 for 22 through the air. Wyoming relinquished 40 attempts on the ground for 196 yds (4.9 yds per carry).

Concerning how much they score, the Cowboys are ranked 128th in Division 1 scoring 17.8 points per contest. The Wyoming Cowboys maintain an average of 329.6 yards per outing, which ranks them 113th in D-1. The Wyoming offense has racked up 585 yards of penalties on 68 infractions, which is 44th in the nation in terms of helping out the other team. They have tossed 11 picks while conceding 6 fumbles and they have tallied 181 first downs. During this campaign so far, the Cowboys have a total of 1,842 passing yards along with holding an average of 184.2 throwing yards per contest, which ranks 107th in college football. They maintain an average of 145.4 yards per game via the rush and have run for 1,454 yards overall.

The Cowboys are surrendering 20.6 points per game, which has them ranked 33rd in Division 1. Wyoming has allowed a total of 1,684 yards on the ground (168.4 yards per game) as well as 12 touchdowns by way of the ground game on the season. They have surrendered 12 touchdowns via the pass in addition to 175.9 yards per game, ranking them 18th in college football. The Cowboys defense has taken the field for 673 plays, which is 78th in D-1. They have 4 fumbles recovered and 9 picks for the season. In total, they have relinquished 206 total points.

Who will win tonight's Wolf Pack/Cowboys college football game against the spread?

Tony's Pick: Take the Cowboys -6.5

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get college football picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.