NIU Huskies vs Mississippi State Bulldogs Prediction, 9/20/2025 College Football Picks, Best Bets & Odds

Game: NIU Huskies vs Mississippi State Bulldogs

Date: Saturday, September 20, 2025

Location: Davis Wade Stadium in Starkville, MS

TV: ESPN/ESPN+

Odds/Point Spread: Bulldogs (-21.5)

Total/Over-Under: 50

The Mississippi State Bulldogs (3-0) will play the NIU Huskies (1-1) at Davis Wade Stadium on Saturday, September 20, 2025. Mississippi State is 21.5-point favorites. The over/under is 50.

The NIU Huskies head into this matchup 1-1 this season. In their last matchup, the Huskies faced off with the Maryland Terrapins and took a loss by a score of 20-9. When it came to the battle of the line of scrimmage, the Huskies gave up 86 yards on 28 tries, which is 3.1 yards per run surrendered. NIU allowed 19 completions on 36 attempts for a total of 254 yds, and a completion rate of 52.8%. In all, they had 70 plays for 271 yards. The NIU Huskies ran the football 48 different times and accrued 180 yds, which came out to an average of 3.8 yards per tote.

The Huskies have racked up 558 yards in total this season. In terms of scoring touchdowns, NIU has compiled 0 touchdowns through the air and 2 touchdowns on the ground. They have turned the ball over 1 time. NIU has earned 30 1st downs, and they have been flagged for 13 infractions for 103 yards. As a unit they are averaging 179.0 yards rushing which is 59th in the country. In terms of putting the ball in the endzone, the NIU Huskies are averaging 14.0 PPG.

In terms of passing yards, the Huskies are giving up 409 yds which has them sitting in 27th in the nation. They have conceded 204.5 yards per outing through the air and allowed a completion percentage of 55.4%. Overall, they have relinquished 278.5 yards per outing which puts them 36th in the nation. They have yielded 3 touchdowns via the pass and 0 touchdowns running the ball. They are giving up an average of 2.7 yards per rushing attempt and 74.0 rushing yards per game for the campaign. Over the course of this year, they have allowed 148 yards via the ground game in 2 contests. The Huskies are ranked 51st in college football in terms of their opponents scoring, allowing 18.5 points per game.

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The Bulldogs head into this matchup 3-0 this season. In their last game, the Bulldogs got the win with a final of 63-0 when they played the Alcorn State Braves. Mississippi State ran the football for 7.8 yds per carry, finishing the game with 282 yards on 36 attempts. The Bulldogs finished the game with 514 yds and they ran 54 plays (9.5 yards per play). The Bulldogs secondary gave up a completion percentage of 61.9%, relinquishing 93 yards on 13 out of 21 passing. Mississippi State allowed 27 run attempts for 68 yards (2.5 yds per rush).

Concerning how much they score, the Bulldogs are sitting 28th in the nation holding an average of 40.3 points per outing. The Mississippi State Bulldogs average 441.3 yards per game, which has them ranked 42nd in the country. The Mississippi State offense has 254 penalty yards on 30 infractions, which has them sitting 1st in Division 1 in terms of helping out the other team. They have thrown 2 interceptions and they have been able to obtain 64 first downs. Over the course of the season so far, the Bulldogs have thrown for a total of 790 yards through the air in addition to an average of 263.3 passing yards per game, ranking them 40th in the country. They average 178.0 yards per game via the ground game and have run for 534 yards for this year.

Mississippi State has allowed a total of 421 yards via the ground game (140.3 yards per outing) as well as 1 touchdown on the ground for the campaign. They have given up 3 touchdowns via the pass as well as 122.7 yards per outing, which has them sitting 14th in D-1. Over the course of the season, they have surrendered 37 pts. Their defense has earned 2 fumbles and 4 interceptions on the season. The Bulldogs defense has taken part in 196 plays, which ranks 71st in college football. The Bulldogs are relinquishing 12.3 points per contest, ranking them 25th in the nation.

Who will win tonight's Huskies/Bulldogs college football game against the spread?

Josh's Pick: Take the Huskies +21.5

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