North Carolina Tar Heels vs Charlotte 49ers Prediction, 9/6/2025 College Football Picks, Best Bets & Odds

Game: North Carolina Tar Heels vs Charlotte 49ers

Date: Saturday, September 6, 2025

Location: Jerry Richardson Stadium in Charlotte, NC

TV: ESPN/ESPN+

Odds/Point Spread: 49ers (+21.0)

Total/Over-Under: 46.5

The North Carolina Tar Heels (0-1) are hitting the road to Jerry Richardson Stadium on Saturday, September 6, 2025 where they will attempt to beat the Charlotte 49ers (0-1). Charlotte is 21.0-point underdogs. The total is set at 46.5.

The North Carolina Tar Heels head into this game 0-1 for this season. The last time they stepped onto the field, the Tar Heels took on the TCU Horned Frogs and went home with a loss by a final score of 48-14. On the ground, the Tar Heels conceded 258 yards on 35 tries, which calculates to 7.4 yards per rush allowed. North Carolina surrendered 27 pass completions on 37 tries for a total of 284 yds, and a completion rate of 73.0%. When all was said and done, they ran 49 plays which gave them 222 yds. The North Carolina Tar Heels ran the rock 28 different times and accumulated 50 yds, which earned them an average of 1.8 yds per carry.

The Tar Heels have racked up 222 total yards for the season. In terms of scoring touchdowns, North Carolina has compiled 1 touchdown through the air and 1 touchdown on the ground. They have given the ball to the opposition 3 times. North Carolina has tallied 10 1st downs as an offense, and they have been hurt by 3 penalties for 25 yards. As a unit they have an average of 50.0 yards via the ground game ranking this team at 129th in the country. Concerning scoring points, the North Carolina Tar Heels are averaging 14.0 points per contest.

The Tar Heels rank 132nd in the nation in terms of team defense, allowing 48.0 PPG. They are giving up an average of 7.4 yards per tote and 258.0 rushing yards per contest this year. Overall, they have given up 258 rushing yards through 1 game. Concerning passing yards, the Tar Heels have given up 284 yds which has them sitting in 116th in D-1. They have relinquished 284.0 yards per game through the air as well as allowing a completion percentage of 73.0%. For the year, they are granting 542.0 yards/game which ranks them 132nd in D-1. They have allowed 2 touchdowns by air in addition to 2 touchdowns via the ground game.

Get all of our College Football Picks this Week

The 49ers come into this matchup with a record of 0-1 for this season. When they last stepped on the field, the 49ers took a defeat with a final score of 34-11 when they played the Appalachian State Mountaineers. Charlotte rushed the ball for 2.6 yds per attempt, finishing with 76 yds on 29 attempts. The 49ers finished the contest with a total of 218 yds while running 54 plays (4.0 yards per play). The 49ers pass defense gave up a completion rate of 66.0%, surrendering 404 yds on 33 out of 50 passing. Charlotte surrendered 38 attempts on the ground for 182 yards (4.8 yds per rush).

The Charlotte 49ers average 218.0 yards/contest, ranking them 127th in D-1. The Charlotte offense has compiled 54 yds of penalties on 7 infractions, which is good for 55th in the country in terms of helping out the other team. They maintain an average of 76.0 rushing yards per game. They have been able to obtain 15 first downs. In terms of their ability to score points, the 49ers are sitting 115th in Division 1 with 11.0 PPG. Over the course of the season to this point, the 49ers have earned 142 passing yards, which is ranked 110th in Division 1.

Charlotte has allowed a total of 182 yards on the ground. They have surrendered 3 touchdowns through the air as well as 404.0 yards per outing, which has them in 135th in Division 1. Their defense has earned 1 fumble recovery over the course of the season. The 49ers defense has participated in 88 plays, ranking them 126th in the nation. The 49ers are relinquishing 34.0 points per game, which has them ranked 118th in the country.

Who will win tonight's Tar Heels/49ers college football game against the spread?

Guy's Pick: Take the Tar Heels -21.0

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here