Notre Dame Fighting Irish vs Pittsburgh Panthers Prediction, 11/15/2025 College Football Picks, Best Bets & Odds

Game: Notre Dame Fighting Irish vs Pittsburgh Panthers

Date: Saturday, November 15, 2025

Location: Acrisure Stadium in Pittsburgh, PA

TV: ABC

Odds/Point Spread: Panthers (-10.5)

Total/Over-Under: 55

The Notre Dame Fighting Irish (6-2) are on their way to Acrisure Stadium on Saturday, November 15, 2025 where they will compete against the Pittsburgh Panthers (7-2). Notre Dame opens as 10.5-point dogs from oddsmakers. The total has been set at 55.

The Notre Dame Fighting Irish come into this game with a record of 6-2 this season. The last time they took the field, the Fighting Irish played the Navy Midshipmen and took home the win by a score of 49-10. When all was said and done, they tallied 57 plays for 502 yards. The Notre Dame Fighting Irish ended up running the ball 38 different times and accounted for 249 yards, which came out to an average of 6.6 yds per attempt. On the ground, the Fighting Irish conceded 206 yds on 45 tries, which is an average of 4.6 yards per rush allowed. Notre Dame conceded 3 pass completions on 10 tries for 22 yds, and a completion rate of 30.0%.

The Fighting Irish have racked up 3,693 total yards over the course of this season. In terms of notching touchdowns, Notre Dame has compiled 16 touchdowns through the air and 22 rushing touchdowns. They have surrendered the football 8 times. Notre Dame has accumulated 188 1st downs as a unit, and they have committed 50 penalties for 448 yards. Offensively they're maintaining an average of 187.6 yards rushing ranking them 29th in the country. In terms of scoring points, the Notre Dame Fighting Irish have an average of 37.4 PPG.

In terms of yards via the pass, the Fighting Irish have allowed 2,069 yds which puts them in 100th in the country. They have yielded 258.6 yards per contest through the air as well as conceding a completion percentage of 58.2%. Overall, they have given up 348.3 yards per contest which ranks them 52nd in the nation. They have yielded 11 touchdowns by air in addition to 6 touchdowns via the ground game. Opposing teams are running for an average of 2.8 yards per running attempt and 89.6 yards on the ground per contest this year. Overall, they have given up 717 yards via the running game in 8 games. The Fighting Irish are ranked 27th in D-1 when it comes to their opponents scoring, allowing 19.9 points per contest.

Get all of our College Football Picks this Week

The Panthers come into this matchup with a record of 7-2 for this season. When they last stepped on the field, the Panthers walked away with a victory by a final of 35-20 against the Stanford Cardinal. Pittsburgh rushed for 4.6 yards per attempt, finishing the game with 162 yds on 35 carries. The Panthers ended up finishing with 466 yds and they ran 73 plays (6.4 yards per play). The Panthers passing defense conceded a completion rate of 61.4%, relinquishing 336 yards on 27 for 44 passing. Pittsburgh gave up 27 run attempts for -10 yds (-0.4 yards per carry).

Concerning the points being put on the board, the Panthers currently rank 8th in college football averaging 39.7 points per outing. The Pittsburgh Panthers are averaging 426.8 yards per outing, ranking them 38th in the country. The Pittsburgh offense has 627 penalty yds on 70 violations, which is good for 6th in college football in terms of making mistakes. They have tossed 12 picks while conceding 4 fumbles and they have been able to tally 196 1st downs. For the year to this point, the Panthers have a total of 2,723 passing yards as well as holding an average of 302.6 passing yards per outing, which has them ranked 10th in D-1. They maintain an average of 124.2 run yards per game and have run for 1,118 yards for the year.

Pittsburgh has conceded a total of 728 rushing yards (80.9 yards per outing) as well as 7 touchdowns via the rush for the year. They have allowed 18 touchdowns via the pass and 237.4 yards/contest, which has them sitting 95th in the country. In total, they have relinquished 196 points. Their defense has totaled 5 fumbles recovered and 10 picks so far this year. The Panthers defense has been on the field for 613 plays, which is 107th in college football. The Panthers are giving up 21.8 PPG, which has them 44th in Division 1.

Who will win tonight's Fighting Irish/Panthers college football game against the spread?

Guy's Pick: Take the Fighting Irish +10.5

Get $60 worth of FREE premium member picks. No Obligation. No Salesman. No Credit Card. Fast Sign up with Instant Access Click Here

Get college football picks on every single game, or if you want our very best bets by the experts, sign up for your free $60 account with a guarantee.