Notre Dame Fighting Irish vs Stanford Cardinal Prediction, 11/29/2025 College Football Picks, Best Bets & Odds

Game: Notre Dame Fighting Irish vs Stanford Cardinal

Date: Saturday, November 29, 2025

Location: Stanford Stadium in Stanford, CA

TV: ESPN

Odds/Point Spread: Cardinal (+32.5)

Total/Over-Under: 51

The Stanford Cardinal (4-7) are welcoming the Notre Dame Fighting Irish (9-2) at Stanford Stadium on Saturday, November 29, 2025. Notre Dame opens this matchup as 32.5-point favorites from oddsmakers. The total comes in at 51.

The Notre Dame Fighting Irish step onto the field holding a record of 9-2 this season. The last time they stepped onto the field, the Fighting Irish played the Syracuse Orange and went home with a win by a final score of 70-7. The Notre Dame Fighting Irish ran the football 24 times and tallied 329 yds, which had them averaging 13.7 yds per carry. When the final whistle blew, they tallied 39 plays which totaled 396 yards. Notre Dame relinquished 17 pass completions on 30 attempts for 95 yards, and a completion rate of 56.7%. On the ground, the Fighting Irish conceded 112 yards on 50 attempts, which is an average of 2.2 yds per run surrendered.

The Fighting Irish have racked up 4,978 total yards for the year. In terms of getting the ball in the endzone, Notre Dame has earned 22 touchdowns through the air and 34 touchdowns via the ground. They have given the ball to the opposition 10 times. Notre Dame has tallied 248 first downs offensively, and they have been hurt by 63 infractions for 587 yds. As a team they're maintaining an average of 204.9 yards rushing giving them a rank of 19th in the country. In terms of getting in the endzone, the Notre Dame Fighting Irish hold an average of 41.4 PPG.

The Fighting Irish are ranked 12th in the country concerning team defense, conceding 17.4 PPG. They are allowing an average of 3.0 yards per run and 100.5 yards on the ground per contest so far this year. For the year, they have conceded 1,106 yards on the ground through 11 games. Concerning passing yards, the Fighting Irish have given up 2,335 yds which has them ranked 59th in D-1. They have conceded 212.3 yards per game via the pass in addition to giving up a completion percentage of 56.3%. During this campaign, they have surrendered 312.7 yards per outing ranking them 22nd in the country. They have surrendered 12 touchdowns by air as well as 8 touchdowns pounding the rock.

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The Cardinal come into this matchup with a record of 4-7 this season. When they last stepped on the gridiron, the Cardinal took home the win by a final score of 31-10 against the California Golden Bears. Stanford ended up running for 4.3 yards per carry, finishing the game with 159 yards on 37 carries. The Cardinal finished with a total of 282 yds while they ran 57 plays (4.9 yds per play). The Cardinal pass defense conceded a completion percentage of 68.0%, surrendering 285 yards on 34 out of 50 passing. Stanford conceded 26 run attempts for 12 yds (0.5 yds per rush).

The Stanford Cardinal maintain an average of 306.0 yards/contest, ranking them 124th in D-1. The Stanford offense has racked up 616 yards of penalties on 69 infractions, which is 60th in D-1 in terms of making mistakes. They have an average of 84.4 run yards per game and have run for 928 yards for the year. They have tossed 11 picks while losing 6 fumbles and they have been able to earn 193 first downs. When it comes to their scoring prowess, the Cardinal rank 124th in Division 1 by scoring 18.7 points per game. Over the course of the season so far, the Cardinal have a total of 2,438 yards via the pass as well as holding an average of 221.6 passing yards per game, ranking them 76th in the country.

The Cardinal are allowing 27.4 PPG, which has them 88th in Division 1. Stanford has conceded a total of 1,244 yards via the ground game (113.1 yards per game) as well as 13 touchdowns via the rush this season. They have conceded 19 touchdowns via the pass in addition to 284.5 yards per game, which has them sitting 135th in Division 1. The Cardinal defense has been on the field for 752 plays, ranking them 97th in the country. Their defense has tallied 10 fumbles recovered and 3 picks so far this season. This season, they have conceded 301 points.

Who will win tonight's Fighting Irish/Cardinal college football game against the spread?

Josh's Pick: Take the Cardinal +32.5

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