Ohio State Buckeyes vs Purdue Boilermakers Prediction, 11/8/2025 College Football Picks, Best Bets & Odds

Game: Ohio State Buckeyes vs Purdue Boilermakers

Date: Saturday, November 8, 2025

Location: Ross-Ade Stadium in West Lafayette, IN

TV: BTN

Odds/Point Spread: Boilermakers (+28.5)

Total/Over-Under: 48.5

Ross-Ade Stadium is where the Purdue Boilermakers (2-6) will try to beat the Ohio State Buckeyes (8-0) on Saturday, November 8, 2025. Purdue opens as 28.5-point dogs. The total is set at 48.5.

The Ohio State Buckeyes come into this game with a record of 8-0 for this season. In their last contest, the Buckeyes faced the Penn State Nittany Lions and took home the win by a score of 38-14. The Ohio State Buckeyes ran the ball 32 times and accounted for 164 yards, which is an average of 5.1 yds per carry. When the final whistle blew, they ran 55 plays which totaled 480 yards. Ohio State relinquished 19 completions on 29 attempts for 145 yds, and a completion percentage of 65.5%. Against the rush, the Buckeyes conceded 55 yds on 31 attempts, which is 1.8 yards per run surrendered.

The Buckeyes have racked up 3,500 total yards for the year. When it comes to distribution of touchdowns, Ohio State has compiled 24 passing touchdowns and 13 rushing touchdowns. They have surrendered the football 5 different times. Ohio State has accrued 179 first downs as a team, and they have been called for 34 penalties for 294 yards. As a team they have an average of 153.3 yards on the ground ranking them 74th in college football. Regarding scoring points, the Ohio State Buckeyes are averaging 36.6 points per outing.

When talking about yards through the air, the Buckeyes have conceded 1,064 yds which ranks them 2nd in D-1. They are giving up 133.0 yards per game through the air and allowed a completion percentage of 60.5%. During the season, they are conceding 214.8 yards per contest ranking them 1st in D-1. They have surrendered 3 touchdowns via the pass and 3 touchdowns on the ground. They are giving up an average of 2.6 yards per run and 81.8 rushing yards per contest this year. For the season, they have conceded 654 rushing yards through 8 games. The Buckeyes rank 1st in Division 1 in terms of the opposition scoring, conceding 6.9 PPG.

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The Boilermakers head into this matchup 2-6 this year. In their last game, the Boilermakers went home defeated by a final of 21-16 when they played the Michigan Wolverines. Purdue ran the ball for 3.5 yds per attempt, finishing the contest with 138 yds on 39 carries. The Boilermakers finished the contest with a total of 276 yards while running 65 plays (4.2 yds per play). The Boilermakers secondary allowed a completion percentage of 59.1%, relinquishing 145 yards on 13 for 22 passing. Purdue surrendered 39 attempts on the ground for 253 yards (6.5 yds per rush).

The Purdue Boilermakers have an average of 375.3 yards/game, which ranks them 75th in the nation. The Purdue offense has totaled 450 yds of penalties on 46 infractions, which ranks 103rd in Division 1 in terms of giving up free yards. They have an average of 141.2 run yards per game and have rushed for 1,271 yards for this season. They have thrown 10 interceptions while surrendering 7 fumbles and they have recorded 188 first downs. When discussing the points being put on the board, the Boilermakers currently sit 108th in D-1 scoring 22.1 points per contest. During the season to this point, the Boilermakers have thrown for a total of 2,107 yards through the air not to mention holding an average of 234.1 passing yards per contest, which has them ranked 66th in the nation.

The Boilermakers are allowing 27.0 PPG, which has them ranked 87th in D-1. Purdue has surrendered a total of 1,445 rushing yards (160.6 yards per contest) as well as 16 touchdowns via the rush for the season. They have yielded 9 touchdowns through the air in addition to 234.4 yards/outing, which has them ranked 91st in college football. The Boilermakers defense has been on the field for 581 plays, ranking them 86th in D-1. Their defense has tallied 4 fumbles recovered and 3 picks for the year. This season, they have relinquished 243 points in total.

Who will win tonight's Buckeyes/Boilermakers college football game against the spread?

Guy's Pick: Take the Buckeyes -28.5

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