Oklahoma Sooners vs South Carolina Gamecocks Prediction, 10/18/2025 College Football Picks, Best Bets & Odds

Game: Oklahoma Sooners vs South Carolina Gamecocks

Date: Saturday, October 18, 2025

Location: Williams-Brice Stadium in Columbia, SC

TV: SEC Network

Odds/Point Spread: Gamecocks (+3.5)

Total/Over-Under: 43

The Oklahoma Sooners (5-1) are headed to Williams-Brice Stadium on Saturday, October 18, 2025 where they will attempt to defeat the South Carolina Gamecocks (3-3). Oklahoma opens as 3.5-point favorites from Vegas oddsmakers. The over/under is 43.

The Oklahoma Sooners head into this matchup 5-1 this year. In their last matchup, the Sooners took on the Texas Longhorns and took a loss by a final of 23-6. In all, they tallied 69 plays which converted into 258 yards. The Oklahoma Sooners ended up running the ball 30 times and had 48 yards, which came out to an average of 1.6 yards per tote. When it came to stopping the run, the Sooners conceded 136 yds on 35 attempts, which averages out to 3.9 yards per rush allowed. Oklahoma allowed 21 completions on 27 tries for 166 yards, and a completion rate of 77.8%.

The Sooners have earned 2,334 total yards this season. When it comes to getting the ball in the endzone, Oklahoma has amassed 9 touchdowns through the air and 10 touchdowns on the ground. They have given the ball to the opposition 9 times. Oklahoma has compiled 129 first downs as a team, and they have been hurt by 34 infractions for 314 yards. As a team they average 122.3 yards on the ground which is 106th in D-1. When it comes to putting the ball in the endzone, the Oklahoma Sooners have an average of 29.2 PPG.

Concerning passing yardage, the Sooners are giving up 758 yds which puts them in 3rd in Division 1. They have allowed 126.3 yards per game through the air as well as conceding a completion percentage of 56.8%. Over the course of this season, they are surrendering 211.2 yards per outing which has them ranked 1st in D-1. They have conceded 2 touchdowns via the pass in addition to 2 touchdowns via the ground game. The opposition is running for 2.7 yards per tote and 84.8 rushing yards per contest this year. Overall, they have allowed 509 yards via the ground game in 6 contests. The Sooners sit in 2nd in D-1 concerning their opponents scoring, conceding 9.8 points per game.

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The Gamecocks come into this matchup with a record of 3-3 this year. When they last played, the Gamecocks went home defeated by a final of 20-10 when they faced the LSU Tigers. The Gamecocks finished the contest with a total of 317 yards while they ran 72 plays (4.4 yds per play). South Carolina ended up running for 4.3 yards per tote, totaling 193 yards on 45 attempts. South Carolina conceded 30 run attempts for 166 yards (5.5 yds per rush). The Gamecocks pass defense allowed a completion percentage of 60.6%, surrendering 254 yards on 20 for 33 through the air.

In relation to this team's ability to score points, the Gamecocks rank 107th in Division 1 averaging 22.3 PPG. The South Carolina Gamecocks maintain an average of 310.0 yards per contest, which ranks them 123rd in the country. The South Carolina offense has 412 yards of penalties on 55 infractions, which has them ranked 3rd in the country in terms of hurting your team. They have thrown 3 picks while conceding 3 fumbles and they have been able to earn 106 1st downs. During this campaign to this point, the Gamecocks have thrown for a total of 1,168 yards through the air together with holding an average of 194.7 passing yards per game, which is ranked 100th in college football. They have an average of 115.3 yards via the ground game and have rushed for 692 yards in total.

The Gamecocks are giving up 19.0 PPG, which has them sitting 32nd in the country. South Carolina has surrendered a total of 882 yards on the ground (147.0 yards per game) and 5 touchdowns by way of the ground game this year. They have surrendered 6 touchdowns via the pass as well as 192.5 yards/outing, which has them sitting 40th in college football. The Gamecocks defense has been on the field for 395 plays, which has them ranked 64th in college football. They have earned 4 fumbles recovered and 8 interceptions so far this year. This season, they have surrendered 114 total points.

Who will win tonight's Sooners/Gamecocks college football game against the spread?

Tony's Pick: Take the Sooners -3.5

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