Oklahoma State Cowboys vs Arizona Wildcats Prediction, 10/4/2025 College Football Picks, Best Bets & Odds

Game: Oklahoma State Cowboys vs Arizona Wildcats

Date: Saturday, October 4, 2025

Location: Arizona Stadium in Tucson, AZ

TV: TNT

Odds/Point Spread: Wildcats (-20.0)

Total/Over-Under: 55.5

The Oklahoma State Cowboys (1-3) are headed to Arizona Stadium on Saturday, October 4, 2025 where they will try to beat the Arizona Wildcats (3-1). Arizona opens this game as 20.0-point favorites. The over/under has been set at 55.5.

The Oklahoma State Cowboys come into this matchup with a record of 1-3 for this season. The last time they stepped onto the field, the Cowboys faced off with the Baylor Bears and went home with a loss by a final score of 45-27. The Oklahoma State Cowboys ended up running the ball 32 different times and compiled 157 yds, earning them an average of 4.9 yards per tote. In all, they tallied 78 plays which totaled 448 yards. Oklahoma State surrendered 24 pass completions on 35 attempts for a total of 393 yards, and a completion percentage of 68.6%. In the running game, the Cowboys conceded 219 yards on 39 tries, which averages out to 5.6 yards per run allowed.

The Cowboys currently have 1,421 total yards this season. When it comes to getting in the endzone, Oklahoma State has totaled 2 touchdowns via the pass and 5 touchdowns via the ground. They have surrendered the ball 2 different times. Oklahoma State has tallied 75 1st downs as an offense, and they have been hurt by 24 penalties for 230 yds. As a unit they average 153.3 yards on the ground giving them a rank of 74th in the country. Regarding scoring points, the Oklahoma State Cowboys are sitting at 17.3 PPG.

In terms of passing yards, the Cowboys are giving up 1,040 yds which ranks them 83rd in the nation. They have allowed 260.0 yards per outing through the air as well as allowing a completion percentage of 66.4%. During this campaign, they are granting 473.0 yards/game which ranks them 130th in Division 1. They have surrendered 9 touchdowns through the air as well as 7 touchdowns on the ground. Opposing teams are running for an average of 5.4 yards per running attempt and 213.0 yards on the ground per game for the campaign. In total, they have allowed 852 rushing yards through 4 games. The Cowboys are ranked 126th in Division 1 in terms of the opposition scoring, allowing 35.0 points per contest.

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The Wildcats come into this game with a record of 3-1 for this season. For their last game, the Wildcats took a loss by a score of 39-14 when they faced the Iowa State Cyclones. Arizona surrendered 47 attempts on the ground for 111 yds (2.4 yds per rush). The Wildcats pass defense allowed a completion percentage of 68.2%, surrendering 288 yds on 15 for 22 passing. The Wildcats finished the game with a total of 360 yds while they ran 72 plays (5.0 yds per play). Arizona ran the ball for 4.5 yards per attempt, finishing the game with 107 yards on 24 carries.

Regarding the points being put on the board, the Wildcats are 59th in the country averaging 31.3 points per outing. The Arizona Wildcats are averaging 418.0 yards/game, which is good for 56th in the nation. The Arizona offense has racked up 220 penalty yds on 27 infractions, which has them ranked 63rd in college football in terms of making mistakes. They have thrown 3 picks while surrendering 1 fumble and they have been able to earn 88 1st downs. For the season thus far, the Wildcats have thrown for a total of 998 yards via the pass in addition to an average of 249.5 throwing yards per outing, which ranks 53rd in D-1. They hold an average of 168.5 rushing yards per game and have rushed for 674 yards in total.

Arizona has allowed a total of 399 rushing yards (99.8 yards per game) in addition to 7 touchdowns via the rush so far this year. They have conceded 0 touchdowns via the pass and 166.8 yards/outing, ranking them 24th in college football. This year, they have relinquished 65 points. They have totaled 3 fumbles and 6 picks this year. The Wildcats defense has participated in 253 plays, which has them sitting 21st in college football. The Wildcats are conceding 16.3 PPG, ranking them 26th in college football.

Who will win tonight's Cowboys/Wildcats college football game against the spread?

Josh's Pick: Take the Cowboys +20.0

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