Ole Miss Rebels vs Kentucky Wildcats Prediction, 9/6/2025 College Football Picks, Best Bets & Odds

Game: Ole Miss Rebels vs Kentucky Wildcats

Date: Saturday, September 6, 2025

Location: Kroger Field in Lexington, KY

TV: ESPN/ESPN+

Odds/Point Spread: Wildcats (+10.0)

Total/Over-Under: 50.5

The Ole Miss Rebels (1-0) are headed to Kroger Field on Saturday, September 6, 2025 where they will try to beat the Kentucky Wildcats (1-0). Ole Miss opens as 10.0-point favorites. The over/under has been set at 50.5.

The Ole Miss Rebels come into this matchup with a record of 1-0 this season. In their last contest, the Rebels played the Georgia State Panthers and took home the win by a score of 63-7. The Ole Miss Rebels ended up rushing 44 different times and compiled 295 yards, which is an average of 6.7 yards per tote. In the game, they had 81 plays for 695 yds. Ole Miss allowed 12 completions on 25 attempts for a total of 69 yards, and a completion percentage of 48.0%. When it came to the battle of the line of scrimmage, the Rebels conceded 191 yds on 35 attempts, which calculates to 5.5 yards per rush surrendered.

The Rebels have earned 695 total yards this year. In terms of getting the ball in the endzone, Ole Miss has compiled 4 touchdowns via the pass and 4 rushing touchdowns. They have turned the ball over 2 times. Ole Miss has amassed 34 first downs, and they have been hurt by 8 infractions for 51 yards. As a unit they're averaging 295.0 yards in the run game ranking this team at 11th in the nation. Concerning scoring points, the Ole Miss Rebels are averaging 63.0 points per contest.

The Rebels sit in 24th in D-1 concerning their opponents scoring, giving up 7.0 PPG. The opposition is running for an average of 5.5 yards per rushing attempt and 191.0 rushing yards per contest on the campaign. Over the course of this season, they have given up 191 rushing yards through 1 contest. Concerning yards via the pass, the Rebels are conceding 69 yds which puts them in 8th in the nation. They are conceding 69.0 yards per game through the air and allowed a completion percentage of 48.0%. Over the course of this season, they are surrendering 260.0 yards/game which ranks them 47th in D-1. They have yielded 1 touchdown through the air.

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The Wildcats step onto the field holding a record of 1-0 for this season. In their last game, the Wildcats took home the win by a final score of 24-16 against the Toledo Rockets. Kentucky ran the ball for 5.1 yards per tote, finishing the game with 220 yds on 43 attempts. The Wildcats finished the game with a total of 305 yards while running 66 plays (4.6 yds per play). The Wildcats pass defense gave up a completion percentage of 57.5%, relinquishing 270 yds on 23 out of 40 through the air. Kentucky gave up 29 rush attempts for 59 yards (2.0 yds per rush).

When looking at the points being put on the board, the Wildcats rank 75th in Division 1 averaging 24.0 PPG. The Kentucky Wildcats hold an average of 305.0 yards per contest, which is good for 101st in D-1. The Kentucky offense has totaled 30 penalty yds on 3 infractions, which ranks 123rd in college football in terms of hurting your team. They have been able to obtain 17 first downs. During this campaign thus far, the Wildcats have compiled 85 yards via the pass, giving them a rank of 131st in the nation. They are averaging 220.0 rushing yards per game.

The Wildcats are surrendering 16.0 points per contest, which has them 68th in college football. Kentucky has conceded a total of 59 yards on the ground. They have surrendered 1 touchdown from the passing game as well as 270.0 yards per outing, ranking them 114th in the country. The Wildcats defense has been on the field for 69 plays, which is 87th in D-1. They have 1 interception for the season.

Who will win tonight's Rebels/Wildcats college football game against the spread?

Tony's Pick: Take the Wildcats +10.0

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