Oregon Ducks vs Penn State Nittany Lions Prediction, 9/27/2025 College Football Picks, Best Bets & Odds

Game: Oregon Ducks vs Penn State Nittany Lions

Date: Saturday, September 27, 2025

Location: Beaver Stadium in University Park, PA

TV: NBC Peacock

Odds/Point Spread: Nittany Lions (-3.5)

Total/Over-Under: 52

The Penn State Nittany Lions (3-0) are hosting the Oregon Ducks (4-0) at Beaver Stadium on Saturday, September 27, 2025. Oregon is 3.5-point dogs. The total comes in at 52.

The Oregon Ducks head into this game 4-0 this season. The last time they stepped onto the field, the Ducks took the field against the Oregon State Beavers and took home the win by a score of 41-7. On the day, they ran 77 plays which converted into 585 yds. The Oregon Ducks ended up rushing 46 different times and amassed 280 yds, which had them averaging 6.1 yards per attempt. On the ground, the Ducks gave up 67 yards on 26 tries, which calculates to 2.6 yds per rush allowed. Oregon surrendered 7 completions on 22 tries for 80 yards, and a completion percentage of 31.8%.

The Ducks have tallied 2,095 total yards this year. When it comes to scoring touchdowns, Oregon has amassed 11 passing touchdowns and 14 touchdowns on the ground. They have turned the football over 1 time. Oregon has compiled 103 first downs offensively, and they have been hurt by 14 penalties for 104 yds. As a unit they have an average of 255.3 yards via the ground game ranking them 10th in Division 1. Regarding scoring, the Oregon Ducks are sitting at 50.8 PPG.

The Ducks rank 9th in Division 1 when it comes to the opposition scoring, allowing 9.3 points per contest. They are giving up 3.3 yards per attempt on the ground and 108.8 rushing yards per game on the campaign. Overall, they have conceded 435 rushing yards through 4 games. Regarding passing yards, the Ducks have allowed 480 yards which puts them in 14th in the country. They have allowed 120.0 yards per game through the air in addition to allowing a completion percentage of 51.1%. During this campaign, they are granting 228.8 yards/outing ranking them 12th in the country. They have surrendered 0 touchdowns by air and 4 touchdowns on the ground.

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The Nittany Lions step onto the field holding a record of 3-0 for this year. In their last game, the Nittany Lions took home the win by a final score of 52-6 against the Villanova Wildcats. Penn State relinquished 36 rushing attempts for 83 yds (2.3 yds per rush). The Nittany Lions secondary allowed a completion rate of 48.1%, surrendering 96 yds on 13 out of 27 passing. The Nittany Lions finished the game with a total of 465 yards while running 69 plays (6.7 yards per play). Penn State rushed the ball for 6.2 yds per attempt, finishing the game with 237 yds on 38 attempts.

Concerning their ability to score points, the Nittany Lions are sitting 13th in college football scoring 44.0 points per outing. The Penn State Nittany Lions hold an average of 437.3 yards per game, which is good for 46th in college football. The Penn State offense has totaled 80 yds of penalties on 11 violations, which has them sitting 130th in Division 1 in terms of giving up free yards. They have thrown 1 picks while losing 0 fumbles and they have been able to tally 73 1st downs. Over the course of the season to this point, the Nittany Lions currently have a total of 731 passing yards along with holding an average of 243.7 passing yards per outing, which has them ranked 59th in the country. They have an average of 193.7 yards per game via the rush and have rushed for 581 yards in total.

Penn State has allowed the opposition a total of 302 yards rushing (100.7 yards per outing) in addition to 0 touchdown by way of the ground game so far this season. They have given up 2 touchdowns through the air as well as 123.3 yards per contest, ranking them 12th in Division 1. This year, they have surrendered 17 pts. They have tallied 3 fumbles recovered and 4 interceptions on the season. The Nittany Lions defense has taken part in 187 plays, which ranks 16th in the country. The Nittany Lions are allowing 5.7 PPG, which has them sitting 3rd in Division 1.

Who will win tonight's Ducks/Nittany Lions college football game against the spread?

Guy's Pick: Take the Ducks +3.5

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