Penn State Nittany Lions vs Ohio State Buckeyes Prediction, 11/1/2025 College Football Picks, Best Bets & Odds

Game: Penn State Nittany Lions vs Ohio State Buckeyes

Date: Saturday, November 1, 2025

Location: Ohio Stadium in Columbus, OH

TV: FOX

Odds/Point Spread: Buckeyes (-20.5)

Total/Over-Under: 43.5

Ohio Stadium is where the Ohio State Buckeyes (7-0) will attempt to defeat the Penn State Nittany Lions (3-4) on Saturday, November 1, 2025. Ohio State opens this game as 20.5-point favorites. The total comes in at 43.5.

The Penn State Nittany Lions head into this matchup 3-4 this year. In their last game, the Nittany Lions faced off with the Iowa Hawkeyes and took a loss by a score of 25-24. On the ground, the Nittany Lions gave up 245 yards on 33 attempts, which is 7.4 yds per run surrendered. Penn State conceded 10 pass completions on 16 tries for a total of 68 yards, and a completion percentage of 62.5%. Overall, they ran 74 plays which gave them 266 yards. The Penn State Nittany Lions ended up running the ball 46 times and totaled 173 yds, which had them averaging 3.8 yards per tote.

The Nittany Lions have racked up 2,485 yards in total for the year. When it comes to distribution of touchdowns, Penn State has compiled 9 touchdowns via the pass and 17 touchdowns via the ground. They have surrendered the ball 7 times. Penn State has tallied 141 first downs as a team, and they have been flagged for 27 penalties for 219 yds. As a unit they're holding an average of 169.6 yards on the ground ranking them 55th in Division 1. Concerning scoring points, the Penn State Nittany Lions have an average of 34.0 points per outing.

The Nittany Lions rank 29th in college football concerning the opposition scoring, allowing 19.4 points per game. They are giving up an average of 4.1 yards per rush and 158.7 rushing yards per game for the campaign. In total, they have conceded 1,111 rushing yards through 7 games. In terms of passing yardage, the Nittany Lions have given up 1,015 yards which has them ranked 3rd in the country. They have relinquished 145.0 yards per outing via the pass as well as conceding a completion percentage of 61.7%. In total, they are giving up 303.7 yards per game which ranks them 20th in the nation. They have yielded 8 touchdowns through the air as well as 8 touchdowns via the ground game.

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The Buckeyes step onto the field holding a record of 7-0 for this year. When they last played, the Buckeyes walked away with a victory by a final of 34-0 against the Wisconsin Badgers. Ohio State ended up running for 3.5 yards per tote, totaling 98 yards on 28 carries. The Buckeyes finished the game with a total of 491 yards while running 70 plays (7.0 yards per play). The Buckeyes pass defense gave up a completion rate of 46.7%, relinquishing 49 yards on 7 out of 15 passing. Ohio State surrendered 31 rush attempts for 95 yards (3.1 yards per rush).

The Ohio State Buckeyes have an average of 431.4 yards/outing, which has them sitting 36th in the nation. The Ohio State offense has racked up 264 yards of penalties on 32 violations, which ranks 126th in D-1 in terms of helping out the other team. They have an average of 151.7 yards per game via the rush and have run for 1,062 yards in total. They have tossed 3 picks while conceding 1 fumbles and they have obtained 157 first downs. When it comes to this team's ability to score points, the Buckeyes are sitting 21st in college football holding an average of 36.4 points per game. For the year so far, the Buckeyes have thrown for 1,958 yards through the air not to mention holding an average of 279.7 passing yards per outing, which ranks 24th in D-1.

Ohio State has allowed a total of 599 yards rushing (85.6 yards per outing) and 1 touchdown rushing for the year. They have conceded 3 touchdowns through the air and 131.3 yards per outing, which puts them in 3rd in the country. Overall, they have allowed 41 total points. Their defense has compiled 5 fumbles and 4 picks on the season. The Buckeyes defense has taken part in 398 plays, which is 2nd in Division 1. The Buckeyes are giving up 5.9 PPG, which has them 1st in D-1.

Who will win tonight's Nittany Lions/Buckeyes college football game against the spread?

Josh's Pick: Take the Nittany Lions +20.5

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