Pittsburgh Panthers vs Florida State Seminoles Prediction, 10/11/2025 College Football Picks, Best Bets & Odds

Game: Pittsburgh Panthers vs Florida State Seminoles

Date: Saturday, October 11, 2025

Location: Doak Campbell Stadium in Tallahassee, FL

TV: ESPN

Odds/Point Spread: Seminoles (-9.5)

Total/Over-Under: 58

Doak Campbell Stadium is where the Florida State Seminoles (3-2) will take on the Pittsburgh Panthers (3-2) on Saturday, October 11, 2025. Florida State opens this contest as 9.5-point favorites from Vegas oddsmakers. The over/under is 58.

The Pittsburgh Panthers come into this game with a record of 3-2 this year. In their last contest, the Panthers played the Boston College Eagles and earned the victory with a final of 48-7. When it came to stopping the run, the Panthers gave up 27 yds on 24 attempts, which averages out to 1.1 yds per run allowed. Pittsburgh gave up 14 completions on 30 tries for 189 yds, and a completion rate of 46.7%. In all, they ran 88 plays which converted into 503 yards. The Pittsburgh Panthers ran the ball 43 different times and recorded 172 yds, which is an average of 4.0 yards per carry.

Concerning putting the ball in the endzone, the Pittsburgh Panthers hold an average of 41.0 PPG. As a team they're holding an average of 116.0 yards rushing giving them a rank of 110th in the nation. The Panthers have racked up 2,115 total yards for the season. When it comes to scoring touchdowns, Pittsburgh has earned 16 touchdowns via the pass and 7 rushing touchdowns. Pittsburgh has accumulated 103 first downs as a team, and they have been hurt by 37 infractions for 324 yards. They have surrendered the ball 8 times.

The Panthers are ranked 38th in the country in terms of their opponents scoring, conceding 19.6 PPG. They are allowing teams to run for an average of 1.7 yards per rush on the ground and 64.6 rushing yards per game on the campaign. During the season, they have allowed 323 rushing yards through 5 games. Regarding yards through the air, the Panthers have given up 1,136 yds which ranks them 64th in Division 1. They have conceded 227.2 yards per game via the pass and allowed a completion percentage of 63.5%. Overall, they are surrendering 291.8 yards per game ranking them 22nd in college football. They have relinquished 7 touchdowns via the pass and 5 touchdowns pounding the rock.

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The Seminoles step onto the field holding a record of 3-2 for this year. The last time they took the field, the Seminoles went home defeated by a final of 28-22 when they faced the Miami Hurricanes. Florida State ran the ball for 3.5 yds per attempt, finishing with 132 yards on 38 carries. The Seminoles finished the game with a total of 404 yards and they ran 83 plays (4.9 yards per play). The Seminoles secondary conceded a completion rate of 74.1%, surrendering 241 yds on 20 for 27 through the air. Florida State allowed 32 running attempts for 97 yards (3.0 yds per rush).

The Florida State Seminoles have an average of 560.8 yards/game, which has them ranked 3rd in the country. The Florida State offense has accrued 228 yards of penalties on 22 violations, which ranks 118th in the nation in terms of helping out the other team. They average 295.4 yards via the ground game and have toted the ball for 1,477 yards in total. They have given away 5 picks while conceding 4 fumbles and they have recorded 139 first downs. In relation to how much they score, the Seminoles are ranking 5th in D-1 scoring 46.8 PPG. During this campaign so far, the Seminoles have thrown for a total of 1,327 passing yards as well as an average of 265.4 throwing yards per game, which ranks 39th in Division 1.

Florida State has given up a total of 543 rushing yards (108.6 yards per game) as well as 4 touchdowns on the ground this season. They have surrendered 9 touchdowns via the pass as well as 195.8 yards per contest, which puts them in 48th in the nation. Over the course of the season, they have allowed 104 points in total. They have tallied 0 fumbles recovered and 6 interceptions this season. The Seminoles defense has taken part in 319 plays, which is 40th in college football. The Seminoles are conceding 20.8 PPG, which has them 46th in Division 1.

Who will win tonight's Panthers/Seminoles college football game against the spread?

Tony's Pick: Take the Seminoles -9.5

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