Pittsburgh Panthers vs Stanford Cardinal Prediction, 11/1/2025 College Football Picks, Best Bets & Odds

Game: Pittsburgh Panthers vs Stanford Cardinal

Date: Saturday, November 1, 2025

Location: Stanford Stadium in Stanford, CA

TV: ACC Network

Odds/Point Spread: Cardinal (+14.0)

Total/Over-Under: 51.5

The Pittsburgh Panthers (6-2) are en route to Stanford Stadium on Saturday, November 1, 2025 where they will go up against the Stanford Cardinal (3-4). Stanford is 14.0-point dogs from Vegas oddsmakers. The betting total comes in at 51.5.

The Pittsburgh Panthers step onto the field holding a record of 6-2 for this season. In their last contest, the Panthers played the NC State Wolfpack and went home with a win by a final score of 53-34. The Pittsburgh Panthers ended up running the ball 33 different times and recorded 106 yards, earning them an average of 3.2 yards per attempt. Once the final whistle blew, they had 82 plays for 529 yards. Pittsburgh surrendered 25 completions on 41 tries for 284 yds, and a completion percentage of 61.0%. Against the run, the Panthers gave up 161 yards on 19 tries, which is an average of 8.5 yards per run surrendered.

When talking about scoring, the Pittsburgh Panthers have an average of 40.3 points per game. As a team they maintain an average of 119.5 yards on the ground which has them sitting 111th in the country. The Panthers currently have 3,375 total yards over the course of this year. In terms of distribution of touchdowns, Pittsburgh has totaled 21 touchdowns via the pass and 14 touchdowns via the ground. Pittsburgh has a total of 171 1st downs offensively, and they have been called for 60 penalties for 534 yards. They have surrendered the football 12 times.

Regarding passing yards, the Panthers are allowing 1,801 yards which has them sitting in 93rd in college football. They are allowing 225.1 yards per game through the air as well as conceding a completion percentage of 61.9%. Over the course of this year, they have allowed 317.4 yards per outing which ranks them 27th in Division 1. They have surrendered 16 touchdowns through the air as well as 7 touchdowns running the ball. They are allowing an average of 2.7 yards per rushing attempt and 92.3 rushing yards per game this year. During the season, they have conceded 738 rushing yards through 8 contests. The Panthers are ranked 49th in the country when it comes to team defense, conceding 22.0 PPG.

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The Cardinal head into this matchup 3-4 for this season. In their last game, the Cardinal took a defeat with a final score of 42-7 against the Miami Hurricanes. Stanford relinquished 44 running attempts for 199 yards (4.5 yards per rush). The Cardinal passing defense gave up a completion rate of 73.3%, relinquishing 205 yards on 22 for 30 passing. The Cardinal finished the game with a total of 144 yds while they ran 53 plays (2.7 yards per play). Stanford rushed the ball for 2.0 yards per carry, finishing with 55 yds on 27 carries.

When discussing the points being put on the board, the Cardinal are ranked 128th in the country maintaining an average of 17.5 PPG. The Stanford Cardinal have an average of 304.8 yards per game, which ranks them 126th in Division 1. The Stanford offense has accrued 432 yards of penalties on 49 violations, which ranks 66th in the country in terms of helping out the other team. They have given away 7 picks while losing 4 fumbles and they have been able to earn 136 first downs. For the year to this point, the Cardinal have earned 1,695 yards through the air not to mention holding an average of 211.9 passing yards per contest, ranking them 88th in Division 1. They are averaging 92.9 yards via the ground game and have toted the ball for 743 yards for the season.

Stanford has yielded a total of 1,020 yards via the ground game (127.5 yards/game) in addition to 11 touchdowns via the rush for the season. They have allowed 14 touchdowns via the pass in addition to 292.3 yards per game, which puts them in 132nd in college football. In total, they have surrendered 236 points in total. Their defense has 4 fumbles and 1 picks on the year. The Cardinal defense has been on the field for 551 plays, which ranks them 106th in the country. The Cardinal are relinquishing 29.5 PPG, which has them sitting 100th in the nation.

Who will win tonight's Panthers/Cardinal college football game against the spread?

Guy's Pick: Take the Panthers -14.0

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