Pittsburgh Panthers vs West Virginia Mountaineers Prediction, 9/13/2025 College Football Picks, Best Bets & Odds

Game: Pittsburgh Panthers vs West Virginia Mountaineers

Date: Saturday, September 13, 2025

Location: Milan Puskar Stadium in Morgantown, WV

TV: ESPN/ESPN+

Odds/Point Spread: Mountaineers (+5.0)

Total/Over-Under: 58

The Pittsburgh Panthers (2-0) are en route to Milan Puskar Stadium on Saturday, September 13, 2025 where they will take on the West Virginia Mountaineers (1-1). West Virginia opens as 5.0-point underdogs. The over/under is set at 58.

The Pittsburgh Panthers head into this matchup 2-0 this season. The last time they stepped onto the field, the Panthers went up against the Central Michigan Chippewas and notched a win by a score of 45-17. The Pittsburgh Panthers ended up running the ball 26 times and accrued 124 yards, which had them averaging 4.8 yards per carry. When all was said and done, they ran 58 plays for 464 yds. Pittsburgh allowed 20 completions on 27 tries for a total of 177 yds, and a completion rate of 74.1%. On the ground, the Panthers conceded 40 yards on 41 attempts, which is 1.0 yards per run allowed.

In terms of getting in the endzone, the Pittsburgh Panthers are averaging 53.0 points per outing. As a team they maintain an average of 141.0 yards in the run game which is 88th in the nation. The Panthers have attained 924 total yards this year. With reference to getting the ball in the endzone, Pittsburgh has earned 9 passing touchdowns and 4 touchdowns via the ground. Pittsburgh has a total of 43 1st downs, and they have been flagged for 9 infractions for 98 yards. They have surrendered the football 2 times.

When it comes to yards through the air, the Panthers are allowing 348 yards which puts them in 51st in the country. They are giving up 174.0 yards per game via the pass in addition to giving up a completion percentage of 68.5%. For the season, they are conceding 212.5 yards/outing which ranks them 15th in college football. They have allowed 2 touchdowns via the pass as well as 1 touchdown via the ground game. They are allowing teams to run for an average of 1.1 yards per rush and 38.5 rushing yards per contest for the campaign. Over the course of this season, they have allowed 77 rushing yards through 2 games. The Panthers sit in 39th in D-1 in terms of team defense, conceding 13.0 points per contest.

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The Mountaineers come into this matchup with a record of 1-1 for this year. In their last game, the Mountaineers took a loss by a final score of 17-10 when they played the Ohio Bobcats. The Mountaineers finished the game with 250 yds on 56 plays (4.5 yards per play). West Virginia rushed the football for 2.6 yds per carry, finishing the contest with 72 yards on 28 attempts. West Virginia relinquished 48 attempts on the ground for 182 yards (3.8 yards per carry). The Mountaineers passing defense gave up a completion rate of 71.0%, surrendering 247 yards on 22 for 31 passing.

When it comes to how much they score, the Mountaineers currently rank 75th in D-1 holding an average of 27.5 points per contest. The West Virginia Mountaineers have an average of 437.5 yards per contest, which is good for 43rd in the nation. The West Virginia offense has accrued 154 yards of penalties on 17 violations, which has them ranked 20th in the country in terms of giving up free yards. They have been able to earn 39 1st downs. During the season to this point, the Mountaineers have thrown for a total of 410 passing yards as well as holding an average of 205.0 passing yards per outing, ranking them 81st in the country. They average 232.5 run yards per game and have run for 465 yards for the season.

The Mountaineers are surrendering 10.0 PPG, ranking them 24th in D-1. West Virginia has surrendered a total of 235 yards rushing (117.5 yards per outing) as well as 1 touchdown via the rush so far this year. They have conceded 1 touchdown via the pass as well as 158.5 yards per contest, ranking them 39th in college football. The Mountaineers defense has taken the field for 138 plays, which has them sitting 102nd in the nation. Their defense has totaled 2 fumbles recovered and 3 interceptions on the campaign.

Who will win tonight's Panthers/Mountaineers college football game against the spread?

Guy's Pick: Take the Mountaineers +5.0

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