Purdue Boilermakers vs Northwestern Wildcats Prediction, 10/18/2025 College Football Picks, Best Bets & Odds

Game: Purdue Boilermakers vs Northwestern Wildcats

Date: Saturday, October 18, 2025

Location: Martin Stadium in Evanston, IL

TV: BTN

Odds/Point Spread: Wildcats (-3.0)

Total/Over-Under: 48

The Purdue Boilermakers (2-4) are hitting the road to Martin Stadium on Saturday, October 18, 2025 where they will meet the Northwestern Wildcats (4-2). Northwestern opens this game as 3.0-point favorites. The over/under has been set at 48.

The Purdue Boilermakers come into this game with a record of 2-4 for this season. The last time they took the field, the Boilermakers took on the Minnesota Golden Gophers and took a loss by a score of 27-20. Against the rush, the Boilermakers conceded 30 yards on 18 attempts, which calculates to 1.7 yds per run allowed. Purdue gave up 21 completions on 45 tries for 232 yards, and a completion percentage of 46.7%. At the end of the game, they had 82 plays which converted into 456 yards. The Purdue Boilermakers rushed the ball a total of 40 different times and tallied 253 yards, which is an average of 6.3 yards per tote.

The Boilermakers have earned 2,452 total yards for the year. When it comes to distribution of touchdowns, Purdue has earned 9 touchdowns via the pass and 10 touchdowns on the ground. They have surrendered the ball 12 different times. Purdue has tallied 145 1st downs as a team, and they have committed 34 infractions for 322 yds. As a unit they average 138.2 yards via the ground game which ranks them 92nd in the country. Regarding getting in the endzone, the Purdue Boilermakers hold an average of 26.5 points per outing.

The Boilermakers are ranked 105th in the country regarding the opposition scoring, giving up 29.3 points per contest. The opposition is running for an average of 3.8 yards per running attempt and 129.3 rushing yards per contest for the campaign. During this campaign, they have allowed 776 rushing yards through 6 games. Concerning yards via the pass, the Boilermakers are giving up 1,474 yards which has them sitting in 105th in college football. They have surrendered 245.7 yards per game through the air and giving up a completion percentage of 62.9%. Overall, they are conceding 375.0 yards/outing which puts them 78th in college football. They have allowed 6 touchdowns via the pass in addition to 11 touchdowns on the ground.

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The Wildcats head into this game 4-2 for this season. The last time they took the field, the Wildcats walked away with a victory by a final of 22-21 against the Penn State Nittany Lions. Northwestern conceded 31 rushing attempts for 137 yards (4.4 yds per carry). The Wildcats pass defense allowed a completion rate of 65.0%, relinquishing 137 yards on 13 out of 20 passing. The Wildcats finished the game with 282 yds while running 68 plays (4.1 yards per play). Northwestern ended up running for 2.8 yds per attempt, finishing with 119 yards on 42 attempts.

The Northwestern Wildcats are averaging 364.5 yards per contest, which ranks them 87th in the country. The Northwestern offense has racked up 179 yds of penalties on 24 infractions, which is 129th in the nation in terms of helping out the other team. They have an average of 183.2 rushing yards per game and have run for 1,099 yards for this season. They have thrown 6 interceptions while surrendering 3 fumbles and they have obtained 128 first downs. Regarding their ability to score points, the Wildcats are ranked 99th in college football holding an average of 23.3 points per outing. During the season thus far, the Wildcats have a total of 1,088 passing yards as well as holding an average of 181.3 throwing yards per contest, which ranks 110th in the nation.

The Wildcats are conceding 17.7 PPG, which has them 24th in D-1. Northwestern has given up a total of 870 yards via the ground game (145.0 yards per game) and 7 touchdowns on the ground this year. They have surrendered 5 touchdowns through the air as well as 160.3 yards/outing, which has them sitting 18th in D-1. The Wildcats defense has participated in 341 plays, which has them ranked 11th in college football. Their defense has compiled 1 fumble and 3 interceptions on the season. Over the course of the season, they have conceded 106 points.

Who will win tonight's Boilermakers/Wildcats college football game against the spread?

Guy's Pick: Take the Wildcats -3.0

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