Purdue Boilermakers vs Notre Dame Fighting Irish Prediction, 9/20/2025 College Football Picks, Best Bets & Odds

Game: Purdue Boilermakers vs Notre Dame Fighting Irish

Date: Saturday, September 20, 2025

Location: Notre Dame Stadium in Notre Dame, IN

TV: NBC Peacock

Odds/Point Spread: Fighting Irish (-27.0)

Total/Over-Under: 55.5

The Purdue Boilermakers (2-1) are on their way to Notre Dame Stadium on Saturday, September 20, 2025 where they will meet the Notre Dame Fighting Irish (0-1). Notre Dame opens this game as 27.0-point favorites from oddsmakers. The total is 55.5.

The Purdue Boilermakers step onto the field holding a record of 2-1 this season. In their last matchup, the Boilermakers took on the USC Trojans and took a loss by a score of 33-17. Against the run, the Boilermakers gave up 178 yds on 40 attempts, which calculates to 4.5 yds per run allowed. Purdue relinquished 17 pass completions on 28 attempts for 282 yards, and a completion rate of 60.7%. At the end of the game, they had 67 plays which totaled 357 yds. The Purdue Boilermakers ran the ball a total of 28 times and accounted for 52 yards, which is an average of 1.9 yards per carry.

Regarding scoring, the Purdue Boilermakers hold an average of 27.3 PPG. Offensively they maintain an average of 119.7 yards on the ground which ranks them 109th in college football. The Boilermakers have racked up 1,174 total yards this season. When it comes to getting in the endzone, Purdue has compiled 5 passing touchdowns and 5 touchdowns via the ground. Purdue has accounted for 75 1st downs as a team, and they have been flagged for 10 penalties for 115 yds. They have given the ball to the opposition 4 different times.

The Boilermakers rank 41st in the nation concerning their opponents scoring, giving up 16.7 points per game. Opposing teams are running for an average of 3.7 yards per tote and 125.0 rushing yards per contest so far this season. During the season, they have given up 375 rushing yards through 3 outings. When it comes to yards through the air, the Boilermakers are allowing 571 yds which has them sitting in 60th in the country. They have relinquished 190.3 yards per contest through the air as well as giving up a completion percentage of 60.4%. In total, they are conceding 315.3 yards per outing which puts them 54th in the country. They have conceded 1 touchdown via the pass in addition to 3 touchdowns pounding the rock.

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The Fighting Irish step onto the field holding a record of 0-1 this year. When they last stepped on the field, the Fighting Irish took a loss by a score of 41-40 when they played the Texas A&M Aggies. Notre Dame relinquished 32 attempts on the ground for 128 yds (4.0 yards per rush). The Fighting Irish passing defense conceded a completion rate of 45.9%, surrendering 360 yds on 17 for 37 passing. The Fighting Irish ended up finishing with 429 yds and they ran 71 plays (6.0 yds per play). Notre Dame rushed for 3.5 yds per attempt, finishing the game with 136 yds on 39 attempts.

Concerning how much they score, the Fighting Irish are sitting 61st in the country scoring 32.0 points per outing. The Notre Dame Fighting Irish average 371.5 yards per game, which ranks them 81st in Division 1. The Notre Dame offense has accrued 46 yds of penalties on 10 infractions, which ranks them 124th in D-1 in terms of hurting your team. They have given away 2 interceptions while allowing opponents to recover 1 fumble and they have been able to obtain 41 1st downs. During this campaign to this point, the Fighting Irish have thrown for a total of 514 yards through the air not to mention holding an average of 257.0 passing yards per game, which ranks 45th in the country. They hold an average of 114.5 yards per game on the ground and have run for 229 yards for this season.

Notre Dame has given up a total of 262 rushing yards (131.0 yards/game) in addition to 4 touchdowns by way of the ground game for the campaign. They have allowed 4 touchdowns through the air as well as 282.5 yards/game, which has them sitting 126th in D-1. Overall, they have given up 68 points in total. They have totaled 0 fumbles and 1 pick over the course of the season. The Fighting Irish defense has taken the field for 137 plays, which is 17th in college football. The Fighting Irish are relinquishing 34.0 points per game, which puts them 119th in D-1.

Who will win tonight's Boilermakers/Fighting Irish college football game against the spread?

Josh's Pick: Take the Fighting Irish -27.0

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