San Jose State Spartans vs Stanford Cardinal Prediction, 9/27/2025 College Football Picks, Best Bets & Odds

Game: San Jose State Spartans vs Stanford Cardinal

Date: Saturday, September 27, 2025

Location: Stanford Stadium in Stanford, CA

TV: ACC Network

Odds/Point Spread: Cardinal (-2.5)

Total/Over-Under: 49.5

The Stanford Cardinal (1-3) will compete against the San Jose State Spartans (1-2) at Stanford Stadium on Saturday, September 27, 2025. Stanford opens this game as 2.5-point favorites. The total comes in at 49.5.

The San Jose State Spartans head into this matchup 1-2 for this year. In their last contest, the Spartans faced the Idaho Vandals and took home the win by a score of 31-28. For the game, they ran 47 plays which totaled 420 yards. The San Jose State Spartans ran the rock 26 times and totaled 198 yards, earning them an average of 7.6 yards per carry. On the ground, the Spartans gave up 152 yards on 43 attempts, which averages out to 3.5 yds per rush surrendered. San Jose State relinquished 18 completions on 32 tries for 232 yards, and a completion percentage of 56.3%.

The Spartans have earned 1,072 total yards for the season. In terms of getting in the endzone, San Jose State has earned 3 passing touchdowns and 4 touchdowns on the ground. They have turned the football over 8 times. San Jose State has 50 1st downs as a unit, and they have been flagged for 11 penalties for 104 yds. As a team they are averaging 119.3 yards rushing which has them sitting 106th in the country. Regarding scoring, the San Jose State Spartans hold an average of 17.3 points per game.

The Spartans rank 94th in D-1 regarding team defense, allowing 27.3 points per contest. The opposition is running for an average of 4.3 yards per rushing attempt and 181.0 rushing yards per game for the year. In total, they have given up 543 yards via the ground game in 3 games. Regarding passing yards, the Spartans are allowing 664 yards which ranks them 41st in the country. They have surrendered 221.3 yards per contest via the pass and giving up a completion percentage of 60.4%. Overall, they are surrendering 402.3 yards/outing which puts them 106th in Division 1. They have surrendered 6 touchdowns through the air as well as 4 touchdowns on the ground.

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The Cardinal head into this matchup 1-3 for this season. The last time they took the field, the Cardinal walked away with a loss by a score of 48-20 when they played the Virginia Cavaliers. Stanford gave up 42 rush attempts for 206 yards (4.9 yds per rush). The Cardinal pass defense allowed a completion rate of 75.0%, surrendering 384 yards on 24 out of 32 passing. The Cardinal ended up finishing with 321 yds on 60 plays (5.4 yards per play). Stanford rushed for 1.1 yards per carry, finishing the contest with 35 yards on 31 carries.

The Stanford Cardinal are averaging 291.8 yards per contest, which is good for 128th in Division 1. The Stanford offense has racked up 185 yds of penalties on 21 violations, which ranks 85th in college football in terms of helping out the opposition. They maintain an average of 111.0 rushing yards per game and have run for 444 yards in total. They have given away 3 picks while conceding 2 fumbles and they have earned 63 1st downs. When it comes to their ability to score points, the Cardinal rank 120th in Division 1 scoring 18.3 PPG. During the season to this point, the Cardinal have racked up 723 yards via the pass as well as an average of 180.8 passing yards per contest, which ranks 110th in college football.

Stanford has allowed a total of 515 yards rushing (128.8 yards per outing) and 4 touchdowns by way of the ground game for the campaign. They have surrendered 8 touchdowns via the pass as well as 275.5 yards per game, which has them in 121st in the country. Over the course of the season, they have given up 118 points in total. They have tallied 3 fumbles and 1 pick so far this season. The Cardinal defense has taken part in 273 plays, which is 103rd in Division 1. The Cardinal are surrendering 29.5 PPG, which has them ranked 110th in the nation.

Who will win tonight's Spartans/Cardinal college football game against the spread?

Guy's Pick: Take the Spartans +2.5

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