San Jose State Spartans vs Wyoming Cowboys Prediction, 10/11/2025 College Football Picks, Best Bets & Odds

Game: San Jose State Spartans vs Wyoming Cowboys

Date: Saturday, October 11, 2025

Location: War Memorial Stadium in Laramie, WY

TV: CBSSN

Odds/Point Spread: Cowboys (+2.5)

Total/Over-Under: 49.5

War Memorial Stadium is the location where the Wyoming Cowboys (2-3) will meet the San Jose State Spartans (2-3) on Saturday, October 11, 2025. San Jose State opens as 2.5-point favorites. The total is 49.5.

The San Jose State Spartans head into this matchup 2-3 this season. In their last contest, the Spartans faced the New Mexico Lobos and walked away with a win by a score of 35-28. In all, they ran 66 plays for 487 yds. The San Jose State Spartans ran the rock 36 times and amassed 153 yards, which came out to an average of 4.3 yds per attempt. In the running game, the Spartans gave up 76 yds on 27 tries, which is an average of 2.8 yds per run allowed. San Jose State conceded 28 pass completions on 40 tries for a total of 344 yds, and a completion rate of 70.0%.

The Spartans have earned 2,083 total yards for the year. When it comes to getting the ball in the endzone, San Jose State has amassed 9 touchdowns via the pass and 6 rushing touchdowns. They have surrendered the football 9 different times. San Jose State has accrued 101 1st downs offensively, and they have been called for 27 penalties for 241 yds. As a team they have an average of 112.4 yards in the run game ranking this team at 114th in Division 1. In terms of putting the ball in the endzone, the San Jose State Spartans are sitting at 23.2 points per outing.

The Spartans rank 98th in Division 1 regarding their opponents scoring, allowing 28.0 points per game. Opposing teams are running for an average of 3.7 yards per run and 131.2 rushing yards per contest on the campaign. In total, they have given up 656 rushing yards through 5 games. When it comes to yards via the pass, the Spartans are conceding 1,452 yds which has them ranked 124th in the country. They have surrendered 290.4 yards per game through the air as well as giving up a completion percentage of 64.6%. Overall, they are conceding 421.6 yards per game ranking them 117th in D-1. They have given up 8 touchdowns by air as well as 9 touchdowns pounding the rock.

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The Cowboys head into this matchup 2-3 for this season. For their last game, the Cowboys walked away with a loss by a score of 31-17 when they played the UNLV Rebels. Wyoming allowed 39 attempts on the ground for 153 yards (3.9 yards per rush). The Cowboys passing defense allowed a completion percentage of 55.0%, relinquishing 102 yds on 11 for 20 passing. The Cowboys finished the contest with a total of 356 yards and they ran 72 plays (4.9 yds per play). Wyoming rushed for 3.9 yards per attempt, finishing with 102 yds on 26 attempts.

Regarding their ability to score points, the Cowboys currently rank 127th in college football with 16.8 PPG. The Wyoming Cowboys have an average of 347.4 yards/contest, which has them sitting 102nd in college football. The Wyoming offense has racked up 326 yards of penalties on 38 infractions, which is good for 31st in D-1 in terms of giving up free yards. They have tossed 3 interceptions while letting opponents recover 4 fumbles and they have been able to obtain 100 first downs. For the season so far, the Cowboys have thrown for 994 yards via the pass along with an average of 198.8 passing yards per contest, putting them at 97th in the nation. They are averaging 148.6 yards per game via the rush and have rushed for 743 yards for the season.

Wyoming has conceded a total of 805 yards via the ground game (161.0 yards per contest) and 6 touchdowns on the ground for the year. They have allowed 6 touchdowns through the air and 177.2 yards per outing, which has them ranked 27th in Division 1. This season, they have conceded 106 total points. Their defense has earned 3 fumbles recovered and 3 interceptions so far this season. The Cowboys defense has been on the field for 328 plays, which ranks them 50th in the nation. The Cowboys are surrendering 21.2 points per game, which puts them 52nd in D-1.

Who will win tonight's Spartans/Cowboys college football game against the spread?

Josh's Pick: Take the Cowboys +2.5

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