SMU Mustangs vs Clemson Tigers Prediction, 10/18/2025 College Football Picks, Best Bets & Odds

Game: SMU Mustangs vs Clemson Tigers

Date: Saturday, October 18, 2025

Location: Memorial Stadium in Clemson, SC

TV: ACC Network

Odds/Point Spread: Tigers (-9.0)

Total/Over-Under: 55

Memorial Stadium is the site where the Clemson Tigers (3-3) will take on the SMU Mustangs (4-2) on Saturday, October 18, 2025. Clemson is 9.0-point favorites. The over/under is 55.

The SMU Mustangs head into this matchup 4-2 for this year. In their last contest, the Mustangs stepped onto the field against the Stanford Cardinal and took home the win by a score of 34-10. The SMU Mustangs rushed the ball a total of 24 different times and accrued 122 yards, earning them an average of 5.1 yards per attempt. For the game, they had 54 plays which gave them a total of 369 yds. SMU conceded 22 pass completions on 41 attempts for a total of 278 yards, and a completion percentage of 53.7%. Against the run, the Mustangs gave up 75 yds on 33 attempts, which averages out to 2.3 yards per run surrendered.

Concerning scoring, the SMU Mustangs are sitting at 34.0 points per game. As a team they average 127.0 yards rushing ranking this team at 100th in D-1. The Mustangs have earned 2,429 total yards for the year. When it comes to distribution of touchdowns, SMU has amassed 15 touchdowns via the pass and 9 touchdowns on the ground. SMU has compiled 129 first downs as an offense, and they have been called for 42 penalties for 407 yds. They have given the ball to the opposition 9 times.

The Mustangs are ranked 56th in the country regarding the opposition scoring, allowing 22.3 points per contest. Opposing teams are running for an average of 3.1 yards per rushing attempt and 107.3 rushing yards per game on the season. During this campaign, they have given up 644 yards via the ground game in 6 outings. Regarding passing yardage, the Mustangs are giving up 1,895 yds which puts them in 134th in D-1. They have yielded 315.8 yards per outing via the pass and allowed a completion percentage of 55.6%. In total, they are surrendering 423.2 yards per game which ranks them 120th in the country. They have conceded 12 touchdowns by air and 4 touchdowns pounding the rock.

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The Tigers head into this game 3-3 this season. For their last game, the Tigers walked away with a victory by a final of 41-10 when they played the Boston College Eagles. Clemson surrendered 32 rush attempts for 85 yards (2.7 yards per rush). The Tigers pass defense allowed a completion rate of 51.7%, relinquishing 136 yds on 15 for 29 passing. The Tigers finished with 504 yards and they ran 76 plays (6.6 yds per play). Clemson ended up running for 5.3 yards per attempt, finishing the game with 226 yds on 43 attempts.

The Clemson Tigers hold an average of 408.8 yards/outing, ranking them 55th in college football. The Clemson offense has totaled 300 penalty yards on 29 violations, which is good for 112th in college football in terms of helping out the opposition. They average 130.0 yards per game via the ground game and have run for 780 yards in total. They have thrown 6 interceptions while losing 5 fumbles and they have been able to obtain 127 1st downs. Concerning this team's ability to score points, the Tigers are ranked 82nd in D-1 by scoring 26.3 points per game. During this campaign thus far, the Tigers have a total of 1,673 passing yards together with holding an average of 278.8 throwing yards per game, which has them ranked 25th in Division 1.

The Tigers are giving up 18.5 PPG, which has them sitting 29th in the nation. Clemson has allowed the opposition a total of 629 yards via the ground game (104.8 yards per contest) in addition to 6 touchdowns on the ground for the season. They have surrendered 5 touchdowns via the pass as well as 217.5 yards/outing, which has them in 65th in Division 1. The Tigers defense has been on the field for 401 plays, which ranks 73rd in the country. They have totaled 3 fumbles recovered and 4 interceptions so far this season. This year, they have given up 111 pts.

Who will win tonight's Mustangs/Tigers college football game against the spread?

Tony's Pick: Take the Mustangs +9.0

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