South Carolina Gamecocks vs Missouri Tigers Prediction, 9/20/2025 College Football Picks, Best Bets & Odds

Game: South Carolina Gamecocks vs Missouri Tigers

Date: Saturday, September 20, 2025

Location: Memorial Stadium in Columbia, MO

TV: ESPN

Odds/Point Spread: Tigers (-13.5)

Total/Over-Under: 46.5

Memorial Stadium is the site where the Missouri Tigers (3-0) will try to defeat the South Carolina Gamecocks (2-1) on Saturday, September 20, 2025. South Carolina opens as 13.5-point underdogs. The over/under comes in at 46.5.

The South Carolina Gamecocks head into this matchup 2-1 for this year. In their last contest, the Gamecocks stepped onto the field against the Vanderbilt Commodores and took a loss by a final of 31-7. Once the final whistle blew, they had 63 plays which gave them a total of 328 yards. The South Carolina Gamecocks ran the football 29 times and amassed 86 yds, which is an average of 3.0 yards per attempt. When it came to the battle of the line of scrimmage, the Gamecocks gave up 146 yards on 37 attempts, which calculates to 3.9 yards per rush surrendered. South Carolina gave up 18 completions on 26 attempts for 177 yards, and a completion rate of 69.2%.

Regarding scoring points, the South Carolina Gamecocks are averaging 23.0 points per game. As a unit they maintain an average of 110.0 yards rushing which ranks them 117th in Division 1. The Gamecocks have tallied 909 total yards this season. When it comes to scoring touchdowns, South Carolina has earned 2 touchdowns via the pass and 3 rushing touchdowns. South Carolina has 52 first downs as a unit, and they have been called for 23 penalties for 184 yds. They have given the ball to the opposition 4 different times.

The Gamecocks sit in 43rd in college football in terms of team defense, allowing 17.3 PPG. They are allowing teams to run for an average of 3.0 yards per rush on the ground and 107.7 rushing yards per contest this season. Over the course of this year, they have given up 323 rushing yards through 3 games. When talking about yards through the air, the Gamecocks have allowed 606 yds which has them sitting in 69th in the country. They are allowing 202.0 yards per outing via the pass and allowed a completion percentage of 57.2%. Overall, they have yielded 309.7 yards per contest which has them ranked 49th in the nation. They have surrendered 3 touchdowns via the pass as well as 2 touchdowns on the ground.

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The Tigers come into this game with a record of 3-0 for this season. When they last played, the Tigers walked away with a victory by a final of 52-10 when they faced the Louisiana Ragin' Cajuns. Missouri rushed for 6.9 yds per carry, totaling 427 yds on 62 attempts. The Tigers finished the contest with a total of 606 yds on 86 plays (7.0 yds per play). The Tigers pass defense conceded a completion percentage of 14.3%, relinquishing 4 yards on 2 for 14 through the air. Missouri conceded 22 attempts on the ground for 117 yards (5.3 yards per rush).

The Missouri Tigers maintain an average of 587.0 yards/contest, ranking them 4th in Division 1. The Missouri offense has accrued 175 penalty yards on 18 infractions, which ranks them 56th in the nation in terms of making mistakes. They are averaging 302.3 yards per game via the rush and have rushed for 907 yards overall. They have thrown 1 pick while letting opponents recover 1 fumble and they have been able to obtain 85 1st downs. When looking at their scoring prowess, the Tigers are ranking 8th in D-1 by scoring 51.7 points per contest. For the season to this point, the Tigers currently have a total of 854 yards via the pass as well as holding an average of 284.7 throwing yards per outing, which has them ranked 27th in the country.

The Tigers are allowing 15.7 points per game, which puts them 39th in the country. Missouri has conceded a total of 302 rushing yards (100.7 yards/game) and 2 touchdowns by way of the ground game for the season. They have conceded 3 touchdowns via the pass as well as 100.0 yards per contest, which has them in 5th in Division 1. The Tigers defense has been on the field for 147 plays, which ranks 19th in Division 1. They have earned 1 fumble and 2 picks this season. This year, they have given up 47 points.

Who will win tonight's Gamecocks/Tigers college football game against the spread?

Josh's Pick: Take the Gamecocks +13.5

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