Stanford Cardinal vs SMU Mustangs Prediction, 10/11/2025 College Football Picks, Best Bets & Odds

Game: Stanford Cardinal vs SMU Mustangs

Date: Saturday, October 11, 2025

Location: Gerald J. Ford Stadium in Dallas, TX

TV: The CW Network

Odds/Point Spread: Mustangs (-18.0)

Total/Over-Under: 55

Gerald J. Ford Stadium is where the SMU Mustangs (3-2) will try to defeat the Stanford Cardinal (2-3) on Saturday, October 11, 2025. SMU is 18.0-point favorites. The total comes in at 55.

The Stanford Cardinal come into this game with a record of 2-3 for this season. The last time they stepped onto the field, the Cardinal faced off with the San Jose State Spartans and went home with a win by a final score of 30-29. The Stanford Cardinal ended up rushing 26 times and recorded 37 yards, earning them an average of 1.4 yards per attempt. Once the final whistle blew, they tallied 69 plays which totaled 481 yds. Stanford surrendered 36 pass completions on 58 attempts for 473 yds, and a completion rate of 62.1%. On the ground, the Cardinal gave up 51 yds on 14 tries, which averages out to 3.6 yds per run allowed.

Regarding scoring, the Stanford Cardinal are averaging 20.6 points per outing. Offensively they maintain an average of 96.2 yards in the run game which has them sitting 126th in D-1. The Cardinal have attained 1,648 total yards for the year. When it comes to getting in the endzone, Stanford has earned 5 passing touchdowns and 5 touchdowns on the ground. Stanford has 86 1st downs as a unit, and they have been called for 32 penalties for 280 yards. They have turned the football over 6 times.

The Cardinal rank 105th in the country when it comes to team defense, conceding 29.4 points per contest. Opposing teams are running for an average of 3.9 yards per rushing attempt and 113.2 rushing yards per game for the season. Overall, they have conceded 566 rushing yards through 5 outings. When it comes to yards via the pass, the Cardinal are allowing 1,575 yds which puts them in 132nd in D-1. They have conceded 315.0 yards per game via the pass as well as conceding a completion percentage of 66.7%. For the year, they have allowed 428.2 yards/game which puts them 121st in Division 1. They have relinquished 11 touchdowns through the air in addition to 4 touchdowns via the ground game.

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The Mustangs head into this matchup 3-2 for this season. The last time they took the field, the Mustangs took home the win by a final score of 31-18 when they faced the Syracuse Orange. The Mustangs finished the contest with a total of 370 yds while running 64 plays (5.8 yds per play). SMU rushed the football for 2.7 yards per attempt, totaling 76 yards on 28 carries. SMU gave up 33 attempts on the ground for 110 yards (3.3 yds per carry). The Mustangs pass defense gave up a completion percentage of 48.9%, surrendering 279 yds on 22 out of 45 through the air.

In relation to putting points on the board, the Mustangs currently rank 44th in Division 1 holding an average of 34.0 PPG. The SMU Mustangs have an average of 412.0 yards/game, which ranks them 56th in college football. The SMU offense has totaled 354 yards of penalties on 35 violations, which is 47th in the nation in terms of hurting your team. They have thrown 6 interceptions while letting opponents recover 3 fumbles and they have been able to earn 112 1st downs. For the season to this point, the Mustangs have thrown for a total of 1,420 yards via the pass as well as an average of 284.0 passing yards per outing, which has them ranked 23rd in D-1. They are averaging 128.0 rushing yards per game and have run for 640 yards for the season.

The Mustangs are surrendering 24.8 PPG, which has them sitting 76th in Division 1. SMU has allowed the opposition a total of 569 yards on the ground (113.8 yards per game) as well as 4 touchdowns rushing on the season. They have allowed the opposition 11 touchdowns through the air and 323.4 yards/outing, which has them ranked 136th in the country. The Mustangs defense has participated in 392 plays, which ranks them 118th in the nation. They have totaled 3 fumbles recovered and 9 interceptions this season. Overall, they have relinquished 124 total points.

Who will win tonight's Cardinal/Mustangs college football game against the spread?

Tony's Pick: Take the Cardinal +18.0

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